travelers' diarrhea

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travelers' diarrhea

Montezuma's revenge, Aztec two-step, E coli enteritis, Turkey trot, Dehli belly Internal medicine A condition defined as '… the passage of at least 3 unformed stools in a 24-hr period … with N&V, abdominal pain or cramps, fecal urgency, tenesmus, passage of bloody or mucoid stools …in a person who normally resides in an industrialized region and who travels to a developing or semitropical country…Diarrhea > 1 wk in 10% of Pts, and > 1 month in 2%; ±20% of Pts are confined to bed for 1-2 days; most diarrhea in travelers is acquired orally and caused by the heat-stable and heat-labile toxins of E coli and Shigella; the intensity of infection depends on water supply quality, and previous host exposure and susceptibility Pathogens on cruise ships Shigella, Salmonella, Vibrio parahemolyticus, Aeromonas hydrophila, Campylobacter jejuni, Plesiomonas shigelloides, V cholerae–non-01, V fluvialis, Yersinia enterocolitica Parasites Giardia lamblia, Entamoeba histolytica, Balantidium coli, Cryptosporidium spp, Dientamoeba fragilis, Isospora belli, Strongyloides stercoralis Viruses Norwalk-like agents, rotavirus Management Rehydration, bismuth subsalicylate, narcotic analogs to slow the motility and T-S if antibiotics are required Prevention Boil it, cook it, peel it, or forget it. See Airline food, Cruise ship-related diarrhea.

travelers' diarrhea

Abbreviation: TD
Diarrhea experienced by visitors, esp. those who go to tropical countries. The most common causes are enterotoxigenic Escherichia coli, amebas, Giardia, Cyclospora, Cryptosporidium, Shigella, Salmonella, and Campylobacter. The disease is common, affecting as many as 40% of travelers to underdeveloped nations. There is no completely effective method of prevention, but avoidance of tap water, fresh fruits and vegetables, iced drinks, or inadequately cooked foods is helpful. Fish and shellfish may contain biotoxins even when well cooked; local residents can provide valuable advice concerning which fish to avoid. Loperamide with a quinolone antibiotic (such as ciprofloxacin) used after the passage of the first loose stool frequently aborts the illness, but children and pregnant women should not take quinolones. As with other forms of diarrhea, rehydration is crucial. Antidiarrheals are used for comfort.
See also: diarrhea

Patient discussion about travelers' diarrhea

Q. What Is Travelers' Diarrhea? I wanted to know- what exactly is travelers' diarrhea?

A. Travelers' diarrhea is the most common illness affecting travelers. Travelers' diarrhea is defined as three or more unformed stools in 24 hours, commonly accompanied by abdominal cramps, nausea and bloating. Each year 20%–50% of international travelers, an estimated 10 million people, develop diarrhea, usually within the first week of traveling. It can occur due to poor sanitary conditions, usually by bacterial infection. Escherichia coli, enteroaggregative E. coli, and Shigella are the most common bacteria involved. High-risk destinations are the developing countries of Latin America, Africa, the Middle East and Asia.

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References in periodicals archive ?
There is a wide range in the severity of travelers' diarrhea, from just a few watery stools a day in a person who is mildly ill to an obviously ill person with severe cramping, repeated vomiting, profuse watery diarrhea, and dehydration.
The dosing regimen was 400 mg (two oral tablets of 200 mg each) taken twice daily (800 mg total daily dose) of rifamycin SV MMX or placebo for three days in the treatment of patients with travelers' diarrhea.
Recommend antibiotic chemoprophylaxis for travelers at high risk for travelers' diarrhea (TD) and those at high risk for complications.
In the Phase III clinical program, Santarus plans to undertake two international multicenter, randomized, double-blind studies, each with up to approximately 300 patients, to assess the efficacy and safety of rifamycin SV MMX 400 mg (2 times 200 mg) oral tablets taken twice daily (800 mg total daily dose) for three days versus placebo in the treatment of patients with travelers' diarrhea.
The filing of the IND is an important milestone in the rifamycin SV MMX clinical program, and we look forward to moving forward with the development of rifamycin SV MMX for patients with travelers' diarrhea," said Gerald T.
Statements included in this press release that are not a description of historical facts are forward-looking statements, including without limitation all statements related to incidence of infectious diarrhea or travelers' diarrhea, the development of prulifloxacin and any planned regulatory filings.
Optimer completed enrollment in the second of two Phase 3 clinical trials examining the safety and efficacy of Prulifloxacin for the treatment of travelers' diarrhea.
Travelers' diarrhea is characterized by diarrhea along with other related symptoms including nausea, vomiting, abdominal pain or cramping, and fecal urgency.
These results demonstrate a significant breadth of antimicrobial activity and support our development of prulifloxacin for the treatment of travelers' diarrhea," commented Michael N.
Prulifloxacin (OPT-99) is an antibiotic currently in a Phase 3 trial for the treatment of travelers' diarrhea, a form of infectious diarrhea.
XIFAXAN([R]) (rifaximin) tablets 200 mg are indicated for the treatment of patients (greater than or equal to 12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
investigated the efficacy of XIFAXAN in the prevention of travelers' diarrhea in 210 U.