In addition, in order to evaluate suspected alterations in the monoaminergic system, we investigated behavioral responses to tranylcypromine
(Tcy), a monoamine oxidase inhibitor.
If patients do not enter remission within 14 weeks, they either switch drugs or add another medication; this pattern can continue for four levels, ending with tranylcypromine
or mir-tazapine plus extended-release venlafaxine.
1), (4) There have been a few reports of iatrogenic CS, however, related to disulfiram, L-dopa-carbi-dopa, and the combination of lithium and tranylcypromine
These drugs include phenelzine, isocarboxazid, and tranylcypromine
The MAOI tranylcypromine
"is a pretty high drug on my list" of alternatives, Dr.
Food and Drug Administration for its Abbreviated New Drug Application for tranylcypromine
sulfate tablets, 10 mg.
phenelzine sulfate (NARDIL(R)) or tranylcypromine
(Parnate), in his experience, causes less weight gain than does phenelzine (Nardil).
Gelenberg sees little likelihood that this drug or its cousins will become available in the United States soon, especially in light of a meta-analysis indicating that older MAOIs such as phenelzine and tranylcypromine
are better at treating depression (Neuropsychopharmacology 20:226-47, 1999).
Irreversible MAO inhibitors include phenelzine, tranylcypromine
, isocarboxazid, hypericin, and nialamide, all of which are non-specific.