Possible reasons for (transient) PPRV RNA persistence are infection of neurons followed by transsynaptic
According to this theory, glaucoma is a result of brain insulin resistance or central insulin signaling impairment, triggering the development of transsynaptic
Ludwig, "Axonal and transsynaptic
(transneuronal) spread of Herpesvirus simiae (B virus) in experimentally infected mice," Histology and Histopathology, vol.
Verret et al., "Transsynaptic
progression of amyloid-[beta]-induced neuronal dysfunction within the entorhinal-hippocampal network," Neuron, vol.
Despite evidence supporting tau spreading through a transsynaptic
or transneuronal propagation pathway, recent work has challenged this view. AAV-mediated human tau (h-tau) expression in neurons by injection into the medial EC in 4-month-old mice produces hyperphosphorylated human tau, where tau oligomers can propagate to the DG granule cell layer at 28 days postinjection.
The viral glycoprotein is essential for transsynaptic
spreading by using cell nicotinic acetylcholine receptors at the neuromuscular junctions (15).
However, as hydroxyamphetamine is usually not readily available and testing is not reliable in children due to possible transsynaptic
degeneration , localizing tests have widely been replaced by magnetic resonance imaging of the head, neck, and upper chest .
Kwon et al., "Transsynaptic
signaling by activity-dependent cleavage of neuroligin-1," Neuron, vol.
Red light produces pupil constriction mediated by cone input via transsynaptic
activation of melanopsin-expressing retinal ganglion cells (RGCs), whereas blue light leads to pupil constriction mediated primarily by direct photoactivation of ipRGCs.
tracing techniques and donor cell label, synaptic connections between fetal retinal sheet transplants and the host retina have been previously reported [72-74].
Neuroligins, a prototypical interaction partner of neurexins, are expressed predominantly at the postsynaptic terminal; coupling to presynaptic neurexins forms transsynaptic
complexes to participate in the formation, differentiation, maturation, and plasticity of functional synapses [3-5].
For the analysis of connectivity and network function, we will use transsynaptic
labeling and in vivo electrophysiology.