(26) Transrenal DNA
(Tr-DNA) is a class of post-apoptotic DNA fragments with 150-200 bp that are able to cross the kidney barrier and be found in urine.
The company's proprietary urine-based molecular diagnostic tests are used in detection of transrenal DNA
(TrDNA) and RNA (TrRNA).
The company has initiated partnering discussions with several companies, whose analytical technologies are synergistic to short transrenal DNA
fragments in urine, complementing its proprietary nucleic acid extraction and processing methodologies.
To establish reference values for plasma CF-DNA and cell-free urine DNA [or transrenal DNA (Tr-DNA)], we collected blood and urine samples from 125 healthy donors with stable renal function, who we recruited through the Blood Donation Center of the Hospital Universitario Central de Asturias (HUCA).
 Nonstandard abbreviations: AR, acute rejection; ATN, acute tubular necrosis; NTX, nephrotoxicity; CF-DNA, cell-free DNA; Tr-DNA, transrenal DNA or cell-free urine DNA; HUCA, Hospital Universitario Central de Asturias; tCF-DNA, total cell-free DNA; ddCF-DNA, donor-derived cell-free DNA; GE, genome equivalents; SRTP, stable renal transplantation patient; PCT, procalcitonin.
Xenomics is a molecular diagnostics company that focuses on the development of DNA-based tests using Transrenal DNA
Early gender detection will be the first application of transrenal DNA
(Tr-DNA) technology for prenatal diagnostics.
The two applications are directed at methods to diagnose and monitor infectious diseases, such as viruses and bacteria, by detecting their transrenal DNA signature sequences in urine, even though the infection is outside the urinary tract and not detectable by traditional means such as cell cultures.
"We are continuing to develop the transrenal DNA diagnostics and expand the range of applications to include infectious diseases caused by a variety of agents," said Dr.