TAP1(redirected from transporter, ATP-binding cassette, major histocompatibility complex, 1)
TAP1A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance. TAP1 pumps degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment.
TAP1 mutations have been tentatively linked to ankylosing spondylitis, type 1 diabetes and coeliac disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.