The biomarkers include two messenger RNA molecules that encode immune system proteins implicated in transplant rejection
and one noncoding RNA molecule that participates in protein production.
The latest patent for VT-346, US 7,585,507, entitled "Nucleic acid molecules and polypeptides for immune modulation", relates to the use of VT-346 in treating immuno-modulatory disorders characterised by inflammation, such as rheumatoid arthritis, transplant rejection
, asthma and inflammatory bowel disease.
Ho said his approach investigates transplant rejection
non-invasively by observing macrophage accumulation in heart tissues using MRI.
One monoclonal antibody treatment for preventing transplant rejection
, called OKT3, is already on the market, but it has been linked to non-Hodgkin's lymphoma (SN:6/2/90, p.
Top 5 Companies in Early Stage Transplant Rejection
and Transplantation Products
Advanced Biotherapy says the development of the investigational drug for corneal transplant rejection
could be applied to preventing organ transplantation someday.
They believe the drug may prevent organ transplant rejection
in 2 ways--first, by diminishing the transplant response to inflammation and second, by protecting blood vessels to the transplanted organ through its v-protectant activity.
Apomate is currently in US trials approved by the Food and Drug Administration (FDA) and government-approved trials in Canada and the United Kingdom for evaluation of cardiac transplant rejection
and for evaluation of patient response to anti-cancer treatment.
Published Study Shows Revimmune[TM] Reduces the Incidence of Chronic Bone Marrow Transplant Rejection
of Host by Approximately 85%, Enabling Bone Marrow Transplant Usage to Cure Chronic Illnesses such as Sickle Cell Anemia
South San Francisco, CA, to expand the hu1124 (antiCD211a) antibody product development program to include transplant rejection
An experimental method using radioactively labeled cells todetect the early stages of transplant rejection
may be practical as either a replacement or a supplement to current techniques that require a series of heart-muscle biopsies, according to a report in the April CIRCULATION.
com/reports/c62812) has announced the addition of "Autoimmune and Inflammation - Transplant Rejection
or Transplantation Drug Pipeline Report" to their offering.