transphosphorylation


Also found in: Encyclopedia.

transphosphorylation

 [trans″fos″for-ĭ-la´shun]
the exchange of phosphate groups between organic phosphates, without their going through the stage of inorganic phosphates.

trans·phos·phor·y·la·tion

(trans'fos-fōr'i-lā'shŭn),
A reaction involving the transfer of a phosphoric group from one compound to another, often with the involvement of ATP, as by the action of a phosphotransferase or kinase.

transphosphorylation

/trans·phos·phor·y·la·tion/ (trans″fos-for″ĭ-la´shun) the exchange of phosphate groups between organic phosphates, without their going through the stage of inorganic phosphates.

trans·phos·phor·y·la·tion

(trans'fos-fōr-i-lā'shŭn)
A reaction involving the transfer of a phosphoric group from one compound to another, often with the involvement of adenosine triphosphate.

transphosphorylation

the exchange of phosphate groups between organic phosphates, without their going through the stage of inorganic phosphates.
References in periodicals archive ?
Tyrosine 845 on the EGFR has been reported to be a site of transphosphorylation by Src kinase (Tice et al.
The dimers subsequently induce transphosphorylation and activate the HER-2/neu receptor (Fig.
Dimerization, transphosphorylation, protein tyrosine kinase activation, and downstream signaling subsequently occur.
Mutagenesis of a critical Lys882 residue to a glutamate residue abolished all evidence of kinase activity, confirming that the observed phosphorylation of Tyr-to-Phe mutants was not a transphosphorylation catalyzed by another kinase.
After ligand binding, KIT undergoes homodimerization, transphosphorylation of tyrosine residues in its intracellular domain, and subsequent phosphorylation of downstream members of the RAS/RAF/MAPK, JAK/STAT, and PI3K/AKT signaling pathways, thus controlling cell proliferation, apoptosis, chemotaxis, and metabolism.