transpeptidation


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trans·pep·ti·da·tion

(trans'pep-ti-dā'shŭn),
A reaction involving the transfer of one or more amino acids from one peptide chain to another, as by transpeptidase action, or of a peptide chain itself, as in bacterial cell wall synthesis.

trans·pep·ti·da·tion

(trans-pep'ti-dā'shŭn)
A reaction involving the transfer of one or more amino acids from one peptide chain to another, as by transpeptidase action, or of a peptide chain itself, as in bacterial cell wall synthesis.
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References in periodicals archive ?
Providing LPXTG tagged antibodies (A penta-peptide as a substrate for transpeptidation reaction) as specific linkage sites for the oligo-glycine-containing payloads, which are mediated by Staphylococcus aureus Sortase A enzyme (186),
It interferes with the bacterial cell wall synthesis and inhibits the enzyme (DD-transpeptidases) which is responsible for the transpeptidation reaction; a vital step to maintain the integrity of cell wall (Chowdhury and Lieberman, 1999).
Through transglycosylation, the pentapeptide is incorporated into peptidoglycan and via transpeptidation crossbridges form to strengthen the peptidoglycan layer.8
In staphylococci, vancomycin, for example, inhibits the second stage of CW synthesis, blocking the transglycosylation step, which subsequently affects transpeptidation [48, 49].
Mechanism of heavy metal ion activation of phytochelatin (PC) synthase blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides.
(7) Piperacillin, like other [beta]-lactam antibiotics, exerts bactericidal activity by inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis of susceptible bacteria.
Their mechanisms have been proved via cell membranes perturbations coupled with the action of a-lactams on the transpeptidation of the cell wall could lead to an enhanced antimicrobial effect of the combinations (15).