translocator

translocator

a MEMBRANE PROTEIN that translocates a substance across a membrane.
References in periodicals archive ?
Furthermore, A[beta] binding to cyclophilin D (CypD) enhances the protein translocation to the inner membrane, favouring the opening of the mitochondrial permeability transition pore, formed by the adenine nucleotide translocator (ANT) and voltage-dependent anion channels (VDACs).
sup][19] Studies have demonstrated that TNF-a mediates oxidative stress by impairing the membrane permeability transition pore proteins, adenine nucleotide translocator, and voltage-dependent anion channel, thereby inducing the pore opening; this causes uncontrolled transport of substances to alter mitochondrial pH, subsequently leading to mitochondrial dysfunction.
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)/aryl hydrocarbon receptor nuclear translocator (ARNT) pathways, required for angiogenesis, are also activated in basal-like tumors, suggesting that HIF1 inhibitors or bioreductive drugs that become activated under hypoxic conditions may benefit patients with basal-like cancers.
All these TAAs share the characteristic 3-domain structure of N-terminal signal peptide and C-terminal outer membrane translocator domain, separated by an internal passenger domain.
Depletion and multiple deletions of mtDNA caused by mutational change in adenine nucleotide translocator (ANT1 [SLC25A4]), thymidine phosphorylase (ECGF1 [TYMP]), mitochondrial thymidine kinase (TK2), deoxyguanosine kinase (DGUOK), succinyl-coenzyme A ligase (adenosine 5'-diphosphate-forming) subunit b (SUCLA2), succinylCoA ligase (GDP-forming) subunit alpha (SUCLG1), optic atrophy 1 protein (OPA1), p53-inducible ribonucleotide reductase (RRM2B), and the mitochondrial inner membrane protein MPV17 have been reported in similar clinical syndromes.
Nematostella was found to possess 68 genes representing 29-32 families, including two proteins that also possess a second domain, the Per-Arnt-Sim, or PAS, domain: (1) the hypoxia inducible factor l[alpha] HIF-1 [alpha]) and (2) the aryl hydrocarbon receptor nuclear translocator (ARNT; Simionato et al.
As part of an ongoing project to identify other proteins which may be affected by TOR or to affect TOR itself, we examined the adenine nucleotide translocator (ANT), a mitochondrial transporter that moves ADP and ATP across the inner mitochondrial membrane.
The adenine nucleotide translocator (ANT) protein is like the nozzle that transports fuel from a gas station pump to a car.
The mitochondrial permeability transition pore (MPTP) is a multiprotein complex comprising cyclophilin D, a mitochondrial peptidylprolyl cis-trans isomerase; voltage-dependent anion channel (VDAC); adenine nucleotide translocator (ANT); and other molecule(s) that forms a channel in the mitochondrial inner membrane [23].
Induction of CYP1A2 is mediated through the hetero-dimerization of ligand-activated AhR in cytosol and aryl hydrocarbon receptor nuclear translocator (ARNT) in nucleus.
The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: studies in ARNT-deficient cells.