translocator

a MEMBRANE PROTEIN that translocates a substance across a membrane.

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Upon ligand binding, the AHR translocates to the nucleus, where it complexes with the AHR nuclear translocator (ARNT).

Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a western diet

Upon binding to aromatic ligands, toxins, drugs, phytochemicals, and sterols, the AhR-ligand complex shuttles from cytoplasm to the nucleus, where it heteromerises with the AhR nuclear translocator (Arnt) to form the transcription complex able to bind to xenobiotic responsive elements (XRE) DNA-binding motifs located in the promoter region of the target drug metabolising genes, such as phase I (mainly, Cyp1 subfamily) and II metabolising enzymes and Nrf2 [156-158].

Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants

The CGA approach may be limited because of probe selection in the Affymetrix Styl array.Among 498 SNPs associated with candidate genes, only 9 were located within exons {CYPJA2, ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2), EPHX1 [epoxide hydrolase 1, microsomal (xenobiotic)], EPHX2, CYP26B1, GSTM3 (glutathione S-transferase mu 3 (brain)], and CYP4B11 and 87 were located within introns.

Single-nucleotide polymorphisms associated with skin naphthyl-keratin adduct levels in workers exposed to naphthalene

Hitherto, the putative components include the voltage-dependent anion channel (VDAC) or porin, localized in the OMM; the adenine nucleotide translocator (ANT) in the IMM; the peripheral benzodiazepine receptor and the Bcl-2 family proteins; the hexokinase boundtoporin; the cyclophilin-D(Cyp-D), a regulatory element in the matrix; glycogen synthase kinase-3b (GSK-3b); and cytochrome c [121-123].

ROS and ROS-Mediated Cellular Signaling

Most TCDD effects are mediated by its binding to the awl hydrocarbon receptor (AhR), leading to AhR nuclear translocation, heterodimerization with aryl hydrocarbon receptor nuclear translocator (ARNT), and binding to xenobiotic responsive elements present in the promoters of target genes (Barouki et al.

Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells

As a member of the PER-ARNT-SIM (PAS) domain family of transcriptional regulators, ligand-activated AhR translocates to the nucleus and heterodimerizes with AhR nuclear translocator (ARNT), leading to toxic responses (Bock 1994).

Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-[alpha] pathway activity in mice

Vpr protein interacts with adenine nucleotide translocator (ANT, a component of mitochondrial permeability transition pore (PTP)) that is implicated in [Ca.sup.2+] influx into mitochondria.

Oxidative Stress during HIV Infection: Mechanisms and Consequences

Because AHR associates with proteasomal complexes consisting of damaged-DNA-binding protein 1, aryl hydrocarbon receptor nuclear translocator, transducin-[beta]-like 3, and cullin 4B and itself possesses E3 ligase activity (Ohtake et al.

A mutant Ahr allele protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming

[38] proposed the participation of the Adenine Nucleotide Translocator (ANT) in the mitochondria as a new mechanism of protection against increased ROS production in aged skeletal muscle.

Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters

Binding of TCDD to AHR causes the dissociation of the receptor from the complex and its translocation into the nucleus, where it dimerizes with the AHR nuclear translocator (ARNT).

Retinoic acid drives aryl hydrocarbon receptor expression and Is instrumental to dioxin-induced toxicity during palate development

Dioxin and the structurally related PCDF chemicals mediate their toxic effect (but with different potencies) mainly as a ligand to the same aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) complex that binds to the xenobiotic responsive element (XRE; also called dioxin-responsive element, DRE) on target DNA.

Perinatal exposure to low doses of dioxin can permanently impair human semen quality

It has been demonstrated in hAPP mice that protein expression of some components of the MPT, such as cyclophilin D (CypD), voltage-dependent anion channel (VDAC), and adenine nucleotide translocator (ANT), is elevated.

Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer's disease?