TOM complex of protein translocators

(redirected from translocase of outer mitochondrial membrane)

TOM complex of protein translocators

(tom kom'pleks prō'tēn trans'lō-kā-tŏrz),
multisubunit protein complex located in the outer membrane of mitochondria; responsible for transport of mitochondrial proteins, encoded in the nucleus and synthesized in the cytosol, into the intermembrane space and inserting the proper proteins into the outer mitochondrial membrane.
See also: OXA complex of protein translocators.
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References in periodicals archive ?
Possible therapies include the development of "corrector" molecules to revert ApoE4 to the less harmful ApoE3 form, and molecular targeting of DNA coregulatory elements of both ApoE and the mitochondrial support protein, Tom40 [TOMM40, translocase of outer mitochondrial membrane 40 homolog (yeast)].
2] Nonstandard abbreviations: AD, Alzheimer disease; ApoE, apolipoprotein E; TOMM40, translocase of outer mitochondrial membrane 40 homolog (yeast).
3] Human genes: APOE, apolipoprotein E; TOMM40, translocase of outer mitochondrial membrane 40 homolog (yeast); BRCA, early-onset breast cancer.