transitional cell carcinoma


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carcinoma

 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.

urothelial carcinoma

a malignant neoplasm derived from transitional epithelium, occurring chiefly in the urinary bladder, ureters, or renal pelves (especially if well differentiated); frequently papillary; these carcinomas are graded according to the degree of anaplasia. So-called transitional cell carcinoma of the upper respiratory tract is more properly classified as squamous cell carcinoma. Transitional cell carcinoma is also a rare tumor of the ovary.

transitional cell carcinoma

a malignant, usually papillary tumor derived from transitional stratified epithelium, occurring most frequently in the bladder, ureter, urethra, or renal pelvis. The majority of tumors in the collecting system of the kidney are of this kind. They have a better prognosis than squamous cell carcinomas in the same site.
enlarge picture
Transitional cell carcinoma of the ureter

transitional cell carcinoma

Bladder cancer, see there.

tran·si·tion·al cell car·ci·no·ma

(tran-zish'ŭn-ăl sel kahr'si-nō'mă)
A malignant neoplasm derived from transitional epithelium, occurring chiefly in the urinary bladder, ureters, and renal pelves.

tran·si·tion·al cell car·ci·no·ma

(tran-zish'ŭn-ăl sel kahr'si-nō'mă)
A malignant neoplasm derived from transitional epithelium.

carcinoma

a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the mammary gland, uterus, intestinal tract, skin and tongue.

acinic cell carcinoma
locally invasive salivary gland tumors of dogs, and rarely other species, composed of glandular epithelium in an acinar pattern.
adenocystic carcinoma, adenoid cystic carcinoma
carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma
alveolar adenocarcinoma.
apocrine carcinoma
see apocrine tumors.
basal cell carcinoma
an epithelial tumor of the skin that seldom metastasizes but has potential for local invasion and destruction. Common in dogs and cats.
basosquamous carcinoma
carcinoma that histologically exhibits both basal and squamous elements.
bronchogenic carcinoma
carcinoma of the lung, so called because it arises from the epithelium of the bronchial tree.
cholangiocellular carcinoma
primary carcinoma of the liver originating in bile duct cells.
chorionic carcinoma
choriocarcinoma.
colloid carcinoma
mucinous carcinoma.
cylindrical cell carcinoma
carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma
a highly malignant primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad.
epidermoid carcinoma
that in which the cells tend to differentiate in the same way as those of the epidermis; i.e. they tend to form prickle cells and undergo cornification.
giant cell carcinoma
carcinoma containing many giant cells.
hepatocellular carcinoma
primary carcinoma of the liver cells.
Hürthle cell carcinoma
see hürthle cell tumor.
carcinoma in situ
a neoplastic entity wherein the tumor cells have not invaded the basement membrane but are still confined to the epithelium of origin; popularly applied to such cells in the uterine cervix.
large-cell carcinoma
a bronchogenic tumor of undifferentiated (anaplastic) cells of large size.
medullary carcinoma
that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma
adenocarcinoma producing significant amounts of mucin.
oat-cell carcinoma
small-cell carcinoma.
papillary carcinoma
carcinoma in which there are papillary excrescences; called also papillocarcinoma.
scirrhous carcinoma
carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma.
carcinoma simplex
an undifferentiated carcinoma.
carcinoma of skin
squamous cell carcinomas occur on the third eyelid, cornea or the eyelid of cattle and horses, on the penis and prepuce of horses, from the mucosa of the frontal sinus to invade the horn core of cattle (called also horn cancer), on the ears of sheep, on the vulva of ewes when the tail is docked too short. In goats the ears, udder, base of the horn and perineum are also susceptible sites. The tumors grow rapidly, show considerable invasiveness and often metastasize to local lymph nodes. In dogs and cats, squamous cell carcinomas are common, particularly on the face and pinnae of white cats. See also squamous cell carcinoma (below).
small-cell carcinoma
a radiosensitive tumor composed of clusters of small, oval, undifferentiated cells that have hyperchromatic nuclei and scant cytoplasm and are typically bronchogenic. Called also oat-cell carcinoma.
spindle cell carcinoma
squamous cell carcinoma marked by fusiform development or rapidly proliferating cells.
stomach carcinoma
squamous cell carcinomas occur in the stomach of the horse and the bovine rumen. The associated clinical syndrome in the horse is one of indigestion and weight loss. Metastasis occurs commonly. In cows there may be vagus indigestion or chronic tympany of the rumen.
transitional cell carcinoma
occurs mainly in the urinary bladder of older dogs. Several structural types may be observed: papillary, polypoid, fungoid or sessile. Metastasis to regional lymph nodes and lungs is possible.
udder carcinoma
occurs rarely in mares and doe goats.
References in periodicals archive ?
Correlation of upper-tract cytology, retrograde pyelography, ureteroscopic appearance, and ureteroscopic biopsy with histologic examination of upper-tract transitional cell carcinoma.
JAVLOR(R) 25 mg/ml solution for infusion has been approved as monotherapy for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen.
Cystoscopic biopsy specimens revealed a grade 3/3 invasive transitional cell carcinoma with marked necrosis.
A recent trend toward using only noninvasive tests to diagnose IC could result in more patients with transitional cell carcinoma being mislabeled as having IC, Dr.
Evaluation of nuclear matrix protein 22 as a tumour marker in the detection of transitional cell carcinoma of the bladder.
Preliminary European results of local microwave hyperthermia and chemotherapy treatment in intermediate or high risk superficial transitional cell carcinoma of the bladder.
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ.
2) The clinical presentation of carcinosarcoma is similar to transitional cell carcinoma of the bladder, and the most common presenting symptom is gross hematuria.
MIB-1 as a proliferative marker in transitional cell carcinoma of the bladder: clinical significance and comparison with other prognostic factors.
We describe the case of an 84-year-old man with a history of transitional cell carcinoma (TCC) of the urinary bladder who had acute cor pulmonale and died within a few hours after the onset of dyspnea.
In particular, we are pleased to have received clearance for the Duet to aid in the monitoring of specific chromosomal aberrations (3, 7, 17 and 9p21 locus) in patients with transitional cell carcinoma of the bladder.
This adds to the Fast Track designation granted by the FDA in 2003 for developing TOCOSOL Paclitaxel for the treatment of patients with metastatic or locally advanced, inoperable transitional cell carcinoma (TCC) of the urothelium.

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