matrix metalloproteinase 3

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matrix metalloproteinase 3

An enzyme encoded on chromosome 11q22.3 which degrades various tissue substrates (e.g., collagens and others).

Cytokine inducers
EGF, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, hourG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
Collagens III, IV, V and IX; gelatin; aggrecan; versican and hyaluronidase-treated versican; perlecan; decorin; proteoglycan link protein; large tenascin-C; fibronectin; laminin; entactin; osteonectin; elastin; casein; α1-AT, α1-ACHYM; antithrombin-III; α2M; ovostatin; Substance P; MBP; GST-TNF/TNF peptide; IL-1β; serum amyloid A; IGF-binding protein-3; fibrinogen and cross-linked fibrin; plasminogen; MMP-1 “superactivation”; MMP-2/TIMP-2 complex; MMP-7; MMP-87; MMP-9; MMP-1.