transient myeloproliferative disorder

transient myeloproliferative disorder

usually transient leukocytosis associated with Down syndrome and generally diagnosed in the first few weeks of life. It is often accompanied by hepatosplenomegaly, pericardial and pleural effusions, hepatic disease, and a pustular rash. Although spontaneous remission occurs in most cases, some affected infants develop a myelodysplastic syndrome or acute leukemia. Also called congenital leukemoid reaction and transient leukemia of infancy.
References in periodicals archive ?
Spontaneous resolution typically occurs; hence, this phase is now referred to as transient abnormal myelopoiesis (previously transient myeloproliferative disorder, transient leukemia).
Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971.
Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome.
It has been referred to in literature by varied nomenclature such as transient leukemia (TL) or transient myeloproliferative disorder (TMPD).
Acute leukemia and the transient myeloproliferative disorder associated with Down's syndrome: morphologic, immunophenotypic and cytogenetic manifestations.
Prenatal diagnosis of transient myeloproliferative disorder via percutaneous umbilical cord blood sampling: report of two cases in fetuses affected by Down's syndrome.
CD61, which stains positively in disease states of AMKL and also stains positive for blasts in transient myeloproliferative disorder, demonstrated a weak 1+.
The transient myeloproliferative disorder (TMD) of Down syndrome, also known as transient abnormal myelopoiesis, characteristically manifests in the first few days of life, with numerous circulating blast cells exceeding the number of blast cells in the bone marrow and spontaneous resolution within a few weeks.
Acute leukemia and the transient myeloproliferative disorder associated with Down syndrome: morphologic, immunophenotypic and cytogenetic manifestations.
Expression of erythroid specific genes in acute megakaryoblastic leukemia and transient myeloproliferative disorder in Down's syndrome.
6) Instead, the condition was referred to as transient myeloproliferative disorder or transient abnormal myelopoiesis.
5,6) Evidence of the clonal nature of the disease favors the hypothesis that transient myeloproliferative disorder or transient leukemia represents a specific form of leukemia.

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