The idea must arise from reading about the Harvard Mouse case and transgenic animals
The Company believes that a major education effort may be required to convince the medical community and the general public that products developed utilizing transgenic animal
technology are efficacious, safe, and ethical.
This project has also used the services of the Transgenic Animal
Support Core to develop mice that have increased ability to produce GSH, and those of the Molecular Biomarker Laboratory Core to test for the expression of the genes associated with GSH production.
Mechanistic studies have been greatly enhanced by Big Blue transgenic animals
that allow "shuttle" mutagenesis studies (9-11).
University of California (Oakland, CA) has patented a non-human transgenic animal
models for Alzheimer's disease (AD) and CAA, wherein the transgenic animal
is characterized by 1) expression of bioactive transforming growth factor-beta or 2) both expression of bioactive TGF-beta and expression of a human amyloid beta precursor protein (APP) gene product.
However, the unique characteristics of the transgenic animal
have also required new statistical methodologies.
High throughput technologies such as transgenic animal
models, which allow quicker evaluation of chemical effects