transforming growth factors

trans·form·ing growth fac·tors (TGF),

two polypeptide growth factors; TGF-α stimulates growth of many epidermal and epithelial cells and is obtained from conditioned media of transformed or tumor cells; TGF-β is obtained from kidney and platelets and controls proliferation and differentiation in many cell types.

trans·form·ing growth fac·tors

(TGF) (trans-fōrm'ing grōth fak'tŏrz)
Two polypeptide growth factors; TGF-α stimulates growth of many epidermal and epithelial cells; TGF-β controls proliferation and differentiation in many cell types.
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Synthesis of messenger RNAs for transforming growth factors [alpha] and [beta] and the epidermal growth factor receptor by human tumors.
Developmental expression of transforming growth factors alpha and beta in mouse fetus.
Regulation of Transforming Growth Factor-Alpha Expression by Thyroid Hormone during the Post-Natal Development of Rat Submandibular and Sublingual Salivary Glands
Sporn, "New class of transforming growth factors potentiated by epidermal growth factor: isolation from nonneoplastic tissues," Proceedings of the National Academy of Sciences of the United States of America, vol.
Lamb, "Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction," Proceedings of the National Academy of Sciences of the United States of America, vol.
Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk
The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture.
Transforming growth factor alpha (TGFA) is expressed at the medial edge epithelium of fusing palatal shelves during craniofacial development.
Association of transforming growth factor alpha polymorphisms with nonsyndromic cleft lip and palate in Iranian population
Sporn, "New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues," Proceedings of the National Academy of Sciences of the United States of America, vol.
Mohan, "Role of transforming growth factor beta in corneal function, biology and pathology," Current Molecular Medicine, vol.
TGF-[beta]: an important mediator of allergic disease and a molecule with dual activity in cancer development
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo.
Effects of red deer antlers on cutaneous wound healing in full-thickness rat models
His topics include agents that trigger apoptosis, cell cycle checkpoints, tumor transforming growth factors and cancer, and transcription factors and cancer.
Apoptosis, Genomic Integrity and Cancer: An Introduction to Interacting Molecules
When one of several specific proteins, most commonly EGF (epidermal growth factor) or TGF-alpha (one of the so-called transforming growth factors), binds to the external portion of the receptor, it pairs with an identical or a similar receptor nearby in the cell's membrane.
Targeted attack: scientists declare war on a protein implicated in some stubborn forms of cancer
Transforming growth factors. Cancer Surv 1985;4:683-705.
Growth factor involvement in progression of prostate cancer

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