transforming growth factors

trans·form·ing growth fac·tors (TGF),

two polypeptide growth factors; TGF-α stimulates growth of many epidermal and epithelial cells and is obtained from conditioned media of transformed or tumor cells; TGF-β is obtained from kidney and platelets and controls proliferation and differentiation in many cell types.

trans·form·ing growth fac·tors

(TGF) (trans-fōrm'ing grōth fak'tŏrz)
Two polypeptide growth factors; TGF-α stimulates growth of many epidermal and epithelial cells; TGF-β controls proliferation and differentiation in many cell types.
References in periodicals archive ?
The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture.
Transforming growth factor alpha (TGFA) is expressed at the medial edge epithelium of fusing palatal shelves during craniofacial development.
The association between CL/P and specific alleles in the transforming growth factor alpha (TGFA) gene suggests that TGFA could be a candidate gene for CL/P (11-15)
Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation.
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo.
Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing.
Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor.
Expression of transforming growth factor beta(1), beta(3), and basic fibroblast growth factor in full-thickness skin wounds of equine limbs and thorax.
His topics include agents that trigger apoptosis, cell cycle checkpoints, tumor transforming growth factors and cancer, and transcription factors and cancer.
1, Short-term effects of transforming growth factors on growth of human prostate cancer cells.
These families include the following: the fibroblast growth factor (FGF) family, the IGF family, EGF, and transforming growth factor a (TGF-[alpha]), all of which are predominantly stimulators of proliferation; retinoic acid, which causes differentiation and invasiveness; and the TGF-[beta] family and vitamin [D.
Androgens and transforming growth factor beta modulate the growth response to epidermal growth factor in human prostatic tumor cells (LNCaP).

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