transforming growth factors

trans·form·ing growth fac·tors (TGF),

two polypeptide growth factors; TGF-α stimulates growth of many epidermal and epithelial cells and is obtained from conditioned media of transformed or tumor cells; TGF-β is obtained from kidney and platelets and controls proliferation and differentiation in many cell types.

trans·form·ing growth fac·tors

(TGF) (trans-fōrm'ing grōth fak'tŏrz)
Two polypeptide growth factors; TGF-α stimulates growth of many epidermal and epithelial cells; TGF-β controls proliferation and differentiation in many cell types.
References in periodicals archive ?
Synthesis of messenger RNAs for transforming growth factors [alpha] and [beta] and the epidermal growth factor receptor by human tumors.
Developmental expression of transforming growth factors alpha and beta in mouse fetus.
Sporn, "New class of transforming growth factors potentiated by epidermal growth factor: isolation from nonneoplastic tissues," Proceedings of the National Academy of Sciences of the United States of America, vol.
Lamb, "Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction," Proceedings of the National Academy of Sciences of the United States of America, vol.
The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture.
Transforming growth factor alpha (TGFA) is expressed at the medial edge epithelium of fusing palatal shelves during craniofacial development.
Sporn, "New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues," Proceedings of the National Academy of Sciences of the United States of America, vol.
Mohan, "Role of transforming growth factor beta in corneal function, biology and pathology," Current Molecular Medicine, vol.
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo.
His topics include agents that trigger apoptosis, cell cycle checkpoints, tumor transforming growth factors and cancer, and transcription factors and cancer.
When one of several specific proteins, most commonly EGF (epidermal growth factor) or TGF-alpha (one of the so-called transforming growth factors), binds to the external portion of the receptor, it pairs with an identical or a similar receptor nearby in the cell's membrane.
Transforming growth factors. Cancer Surv 1985;4:683-705.

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