transforming growth factor alpha

trans·form·ing growth fac·tor α (TGFα),

a cytokine made by tumor and transformed cells that is associated with growth and differentiation. It is also made in normal tissues during embryogenesis and in certain adult tissues.
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Lead researcher Magda Guerra-Crespo chronicles the success of a small protein called transforming growth factor alpha, which plays critical tissue-forming and developmental roles in humans from just after conception through birth and into old age.
Our model in mice mimics these diseases by activating this pathway in the lungs with a growth factor called transforming growth factor alpha.
Activation of the autocrine transforming growth factor alpha pathway in human squamous carcinoma cells.
Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer.
Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationship with tissue androgen levels.
The researchers used their system to test the effects of cell-stimulating compounds such as epidermal growth factor, transforming growth factor alpha and transforming growth factor beta-1.
Residing on the surfaces of these tumor cells, EGF receptors are activated when naturally occurring proteins in the body, such as epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha), bind to them.
Residing on the surface of these tumor cells, EGFr is activated when naturally occurring proteins in the body, epidermal growth factor (EGF) or transforming growth factor alpha (TGF alpha), bind to it.
Endogenous factors--including epidermal growth factor, transforming growth factor alpha, insulin, insulin-like growth factor-1, insulin-like growth factor-2, and glial cell-line-derived neurotrophic factor (GDNF)--have been shown to play roles in the renewal and repair of damaged populations of hair cells in the mammalian labyrinth.
They then spliced this altered gene to others coding either for a growth factor like transforming growth factor alpha (TGFa) or for interleukin-2 (IL-2).
Residing on the surface of these tumor cells, EGFr is activated when naturally occurring proteins in the body, such as epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha), bind to it.
Under the terms of the agreement, NIH researchers will conduct a non-human primate study to evaluate the potential of Kaleidos Pharma's proprietary compound, Transforming Growth Factor alpha (TGF alpha) to increase CD4 T-cell counts in rhesus monkeys infected with Simian Immunodeficiency Virus (SIV), the ape or monkey equivalent of Human Immunodeficiency Virus (HIV).

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