Additionally, PIM is more frequently identified in the endocervix and the transformation zone
The loop size is chosen according to the size of the lesion and the transformation zone
. Patients are then followed up with cervical smears at 6-monthly intervals for 3 smears and annually thereafter.
The large loop excision of the transformation zone
(LLETZ) is commonly performed to treat these abnormalities.
Excision or ablation of the transformation zone
are equally effective for treating an initial diagnosis of cervical intraepithelial neoplasia (CIN) grades 2 or 3 in women with a satisfactory colposcopy and no suggestion of microinvasive or invasive disease (strength of recommendation [SOR]: A, based on randomized controlled trials [RCTs]).
There are also intraepithelial lymphocytes (IELs) in the ectocervix and the transformation zone
(TZ) which are mostly CD8+ and less frequently CD4+ (31,32).
In view of the uncertainty of the natural history in HIV-infected women, our management in 2006 was more aggressive, and they were treated with large loop excision of the transformation zone
(LLETZ) even when colposcopy suggested CIN1.
The area where cervical cells are most likely to become cancerous is called the transformation zone
. This is the area just around the opening of the cervix that leads on to the endocervical canal (the narrow passageway that runs up from the cervix into the womb).
However, the reservoir and closure pressures in the transformation zone
in the deep reservoir are fluctuant.
Relevance of random biopsy at the transformation zone
when colposcopy is negative.
Histologic and colposcopic studies have documented that in about 90% of cases the initial neoplastic events in the epithelium of the cervix take place in the area of squamous epithelium adjacent to the columnar epithelium, known as the transformation zone
. It is assumed that only a relatively small proportion of squamous intraepithelial lesions will progress to invasive cancer, with the probability of progression increasing for high-grade lesions.
The film was returned to the manufacturer for processing and then interpreted by a single cervicography-certified gynecological oncologist as follows: negative if normal; atypical if there was evidence of an acetowhite lesion of doubtful significance either inside or outside the transformation zone
or if there was evidence of atypical immature squamous metaplasia; positive if there was evidence of a minor-or major-grade lesion or cancer; and technically defective if the film was technically uninterpretable.
Immunological microenvironments in the human vagina: mediators of cellular immunity are concentrated in the cervical transformation zone
. Biol Reprod.