transformation zone


Also found in: Acronyms.

trans·for·ma·tion zone

zone on the cervix at which squamous epithelium and columnar epithelium meet; changes location in response to a woman's hormonal status.

transformation zone

Gynecology The area of actively maturing epithelium between the current squamocolumnar junction–SCJ and the original squamous epithelium Composition Intermingled squamous and columnar epithelium–squamous metaplasia, islands of columnar epithelium, gland openings, Nabothian cyst; > 90% of neoplasia arises from the TZ; cervical colposcopy is inadequate unless the TZ is fully visualized; its location varies in relation to the ectocervix and endocervix, related to Pt age and degree of squamous metaplasia. See CIN.

transformation zone

Any area of the body where squamous epithelium meets columnar epithelium.
See: squamocolumnar junction
References in periodicals archive ?
Additionally, PIM is more frequently identified in the endocervix and the transformation zone than elsewhere.
The loop size is chosen according to the size of the lesion and the transformation zone. Patients are then followed up with cervical smears at 6-monthly intervals for 3 smears and annually thereafter.
The large loop excision of the transformation zone (LLETZ) is commonly performed to treat these abnormalities.
Excision or ablation of the transformation zone are equally effective for treating an initial diagnosis of cervical intraepithelial neoplasia (CIN) grades 2 or 3 in women with a satisfactory colposcopy and no suggestion of microinvasive or invasive disease (strength of recommendation [SOR]: A, based on randomized controlled trials [RCTs]).
There are also intraepithelial lymphocytes (IELs) in the ectocervix and the transformation zone (TZ) which are mostly CD8+ and less frequently CD4+ (31,32).
In view of the uncertainty of the natural history in HIV-infected women, our management in 2006 was more aggressive, and they were treated with large loop excision of the transformation zone (LLETZ) even when colposcopy suggested CIN1.
The area where cervical cells are most likely to become cancerous is called the transformation zone. This is the area just around the opening of the cervix that leads on to the endocervical canal (the narrow passageway that runs up from the cervix into the womb).
However, the reservoir and closure pressures in the transformation zone in the deep reservoir are fluctuant.
Relevance of random biopsy at the transformation zone when colposcopy is negative.
Histologic and colposcopic studies have documented that in about 90% of cases the initial neoplastic events in the epithelium of the cervix take place in the area of squamous epithelium adjacent to the columnar epithelium, known as the transformation zone.[12] It is assumed that only a relatively small proportion of squamous intraepithelial lesions will progress to invasive cancer, with the probability of progression increasing for high-grade lesions.
The film was returned to the manufacturer for processing and then interpreted by a single cervicography-certified gynecological oncologist as follows: negative if normal; atypical if there was evidence of an acetowhite lesion of doubtful significance either inside or outside the transformation zone or if there was evidence of atypical immature squamous metaplasia; positive if there was evidence of a minor-or major-grade lesion or cancer; and technically defective if the film was technically uninterpretable.
Immunological microenvironments in the human vagina: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol Reprod.

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