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A protein that binds guanine nucleotides (that is, a G protein), found in retinal rods and cones, that plays a major role in signal transduction; in vertebrate rod cells it acts as a link of the photolysis of rhodopsin to the activation of cGMP phosphodiesterase.
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The G protein subunit gamma 2 (GNG2), G protein subunit gamma transducin 1 (GNGT1), and G protein subunit alpha 01 (GNA01) genes were involved in 6 significantly enriched pathways and accounted for 0.040% of the genetic variance for MY, 0.027% for FY, and 0.020% for AFC (Supplementary File SI).
Mapping of a novel locus for achromatopsia (ACHM4) to 1p and identification of a germline mutation in the [alpha] subunit of cone transducin (GNAT2).
Yu et al., "Transducin ([beta])-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway," Oncogene, vol.
Finally, functional proteins involved in phototransduction pathway, [alpha]-subunit of cGMP-phosphodiesterase (PDE6[alpha]) and [alpha]-subunit of rod transducin (Gt[alpha]-1), were also detected in urine-derived photoreceptors at W25 and located in the developing outer segment (OS) region of the cells (Figures 5(l) and 5(m)).
Wildman et al., "Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells," Nature, vol.
Recently, mutations of the immunoglobulin super family member 1 (IGSF1) and transducin [beta]-like protein 1 (TBL1X) genes have also been described as causes (2,3).
"Light-dependent compartmentalization of transducin in rod photoreceptors." Molecular Neurobiology.
During visual impulses, the coupling of cGMP-phosphodiesterase and rhodopsin transducin is activated by transducin [22].
For instance, the Walker A sequence motif was found in a variety of nucleotide-binding proteins that include the alpha and beta subunits of ATP synthase, myosin, transducin, helicases, kinases, and RecA [1].
661W cells behave as photoreceptor cells and express blue and green cone pigments, transducin, and cone arrestin, but they do not express retinal pigment epithelial cell-specific proteins.
Liu et al., "Transducin ([beta])-like 1 X-linked receptor 1 promotes proliferation and tumorigenicity in human breast cancer via activation of beta-catenin signaling," Breast Cancer Research, vol.
Phosducin, a light-regulated phosphoprotein, binds to subunits of transducin, a transducer G protein (Lee et al., 1987; Savage et al., 2000), and this lowers levels of cGMP and triggers changes in ionic permeability (including the closure of Na+ channels).