transdifferentiation


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transdifferentiation

(trănz″dĭf″ĕ-rĕn″shē-ā′shŭn)
The conversion of stem cells derived from one tissue into cells normally found in another tissue.

transdifferentiation

see alveolar2. Metaplasia.
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TGF-P also induces fibrogenic transdifferentiation of tubular epithelial cells to harbor ECM-producing character (Li et al.
Moreover, TGF-[beta]1 is a master inducer of epithelial-mesenchymal transition (EMT) in alveolar epithelial cells and transdifferentiation of quiescent fibroblasts into myofibroblasts (MFb), which contribute to ECM deposition (Todd et al.
Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation.
A few possible pathways have been proposed to explain this extraordinary phenotypic conversion, including dedifferentiation, common progenitor, and transdifferentiation mechanisms (Figure 2).
Relatively few laboratories have reported direct transdifferentiation techniques.
As far as I know, no one has ever achieved transdifferentiation by using a single protein-a protein that potentially could be used as a therapeutic," said Lerner.
Hepatic fibrosis is an accumulation of the extracellular matrix that results from hepatic stellate cell transdifferentiation to myofibroblasts trigged by necroinflammation of hepatocytes.
The extent to which brown adipose tissue is lost or replaced by white adipose tissue and/or undergoes a process of transdifferentiation remains controversial.
At the tissue level, the genetically engineered mice also had less inflammation; diminished activity of the enzymes metalloproteinase 2 and 9, which are involved in heart remodelling; and reduced myofibroblast transdifferentiation (a process in which cells near an injury site transform into myofibroblasts, which are cells that help heal injured tissue).
Neurogenin3 is sufficient for transde-termination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes.