Previous studies demonstrated the transdifferentiation
of human dental pulp cells into neuron-like cells,22 oligoprogenitors,23 cardiomyocytes,24 and insulin producing cells.25 Above mentioned studies provide evidence in favor of regenerative potential of dental pulp MSCs.
That occurs due to primary hyperparathyroidism, chronic inflammation, and drugs, such as glucocorticoids, which promotes the transdifferentiation
of vascular smooth muscle cells to an osteogenic phenotype with subsequent vascular calcification (Sebastian et al., 2017).
"This study further validates that the transdifferentiation
process, which is the conversion of one adult tissue or cell into another type of cell, with its distinct phenotype and function, works," said CSO Sarah Ferber.
Impaired expression of the gastric morphogenic factor sonic hedgehog by parietal cells and increased expression of the pancreatic morphogenic factor PDX1 seem to be crucial for the development of pancreatic transdifferentiation
. Altered expression of the morphogenic factors is partly caused by changes in the gastric milieu.
However, increased TGF[beta] levels in stroma stimulate stromal expansion, fibroblast-myofibroblast transdifferentiation
, angiogenesis, extracellular matrix remodeling, degradation, and EMT, thus resulting in facilitation of metastatic spread (40).
potential of limbal fibroblast-like cells.
The exact mechanism of fibroblast transdifferentiation
to myofibroblasts is still unclear.
The aim of this research was to evaluate differential gene expression during transdifferentiation
of BMSC into oligodendrocytes in the presence of CSF.
Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation
into multiple skin cell type.
The prevailing theory is that this decrease in the I:G ratio is caused by beta-cell apoptosis and transdifferentiation
to alpha cells.
As is the case for MyoD-induced transdifferentiation
, direct reprogramming is basically achieved by inducing the transcription factors that govern the transcriptional network of the target cell lineage (33)-(35) (Fig.
This process requires the cells to undergo transdifferentiation
along the way, in order to adapt to new functions after the relocation (Gold and Jacobs, 2013).