Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation
and modes of tissue repair - Current views.
Epithelial-mesenchymal transition is an important process in embryonic development that has been associated with cancer progression and metastasis, and loss of ECAD is considered a key initial step in the transdifferentiation
of epithelial cells into a mesenchymal phenotype (16-19).
5) A similar phenomenon was also reported for transdifferentiation
of mesophyll cells of Zinnia elegans into xylem cells termed tracheary elements.
27 Since the engraftment of transplanted cells remains low in most of the clinical trials so far, the potential benefits could be due to paracrine effect as opposed to transdifferentiation
of injected cells into cardiomyocytes.
They ran a series of carefully crafted experiments and concluded in 2002 that transdifferentiation
of bone-marrow cells essentially didn't exist (beyond the cells' well-known ability to change into various types of blood cells).
E)r Valery Shevchenko (Biopredict International, Saint Gregoire, France) outlined applications of the human cell line HepaRG[TM], which are terminally differentiated hepatic cells derived from a human hepatic progenitor cell line that retains many characteristics of primary human hepatocytes and can undergo differentiation and transdifferentiation
of prostate cancer cells to a neuroendocrine cell phenotype in vitro and in vivo.
Spermatogonial stem cells, in vivo transdifferentiation
and human regenerative medicine.
Another possibility is that biliary MANECs originate from transdifferentiation
Turritopsis dorhnii--and, the theory went, this relative--had the capacity, unique in nature, to revert to its polyp stage when threatened or damaged, a mechanism called transdifferentiation
They also secrete high amounts of insulin and C-peptide, making the cells an excellent research tool in the field of diabetes and for other beta cell-related studies, such as beta-cell function, screening of compounds that regulate insulin secretion, GSIS studies, incretin response, pancreatitis research, and transdifferentiation
To ensure the success of the project, direct transdifferentiation
of fibroblasts into neurons, without an intermediate stem cell stage, will also be attempted as an alternative strategy for generating patient-specific neural cell models.