Many studies have explored the use of high-throughput transcriptional profiling
in rodent models (Eichner et al.
First, transcriptional profiling
established that metastatic tumors had markedly dedifferentiated when compared to tissue-specific expression profiles of genes that distinguish both normal tissue types and primary tumors.
Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University as well as Capital University of Medical Sciences applied single-cell transcriptional profiling
to identify cell types in the developing human PFC and their developmental features.
In particular, "transcriptional profiling
of melanoma cell lines has suggested that Wnt/beta-catenin signaling regulates a transcriptional signature predictive of less aggressive melanoma," they wrote.
In the current study, we used transcriptional profiling
to evaluate global changes in metabolic gene expression following short-term IFN-[alpha] stimulation (<4 hours) in two well-characterized primary macrophage model systems: mouse bone marrow-derived macrophages (BMM) and human monocyte-derived macrophages (MDM).
In the current study, therefore, we analyzed the transcriptional profiling
of human PMNs in response to iRBCs by using oligonucleotide microarrays as a step toward understanding the role of cells in the immunopathogenesis of malaria.
Ramilo, "Transcriptional profiling
in infectious diseases: ready for prime time?" Journal of Infection, vol.
Identification of a novel reference gene for apple transcriptional profiling
under postharvest conditions.
Genome-wide transcriptional profiling
of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes.
The researchers therefore employed transcriptional profiling
of developing TH17 cells to develop a model of their signaling network and establish the major nodes that regulate the development of TH17.
Molecular studies of MPBC to date have predominantly used IHC, fluorescence in situ hybridization, and mRNA transcriptional profiling
techniques and have demonstrated that MPBC clusters with the TNBC/basaloid phenotypes.