PGC-1[alpha] is an auxiliary transcription activating factor (transcriptional coactivator
) that modulates of energy metabolism.
PPAR-y coactivator 1 alpha (PGC1-[alpha]) is highly expressed in the brain and acts as a critical transcriptional coactivator
for mitochondrial biogenesis and cellular energy metabolism.
Zhao et al., "The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
," Nature, vol.
PGC1[alpha] is a transcriptional coactivator
that modulates the expression of UCP1 and then stimulates thermogenesis and the browning of WAT [35-37].
(17) Interestingly, STAT3 and Smad1 form a complex bridged by a transcriptional coactivator
, p300 or CREB binding protein (CBP), and synergistically induce astrocytic gene expression.
We further investigated whether the mechanisms of action of low-[omega]3FA and SP on EtOH-induced decrease in fatty acid oxidation are mediated via the regulation of the transcriptional coactivator
PGC1[alpha], SIRT1, and the downstream pathway.
We asked whether immunohistochemistry directed toward NF2 (merlin), LATS2, and their downstream effector YAP/TAZ (a complex of Yes-associated protein and transcriptional coactivator
with PDZbinding motif) (6) could serve as adjunctive tests when a question of mesothelioma versus a benign reaction arises.
Materials and Methods: We utilized a rotary cell culture system (RCCS) to study the role of transcriptional coactivator
with PDZ-binding motif (TAZ) in simulated MG.
Interestingly however, the molecular mechanisms that mediate the health beneficial effects of exercise, or those that trigger the pathological changes in diseases, are largely unknown.The transcriptional coactivator
peroxisome proliferator-activated receptor ?
PGC-1[alpha] is a crucial transcriptional coactivator
for mitochondrial biogenesis and fatty acid oxidation.
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator
For example, the key glucagon-responsive transcription factor CREB-regulated transcriptional coactivator