transcriptional coactivator

transcriptional coactivator

a cofactor that stimulates transcription by binding at particular sites on DNA.
See also: coactivator.
References in periodicals archive ?
The transcriptional coactivator peroxisome proliferator-activated receptor ?
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator pgc1-alpha.
CBP is a general transcriptional coactivator that functions to regulate gene expression through interaction with various transcription factors, including CREB (Giordano and Avantaggiati 1999), Elk 1 (Janknecht and Nordheim 1996), c-Jun (Giordano and Avantaggiati 1999), and TBP (TATA box binding protein) (Goodman and Smolik 2000).
PGC-1[alpha] is a transcriptional coactivator that interacts with a broad range of transcriptional factors and nuclear receptors, increasing the probability of certain genes related to adipogenesis of being transcribed.
Washington, Mar 4 (ANI): Scientists have found that "knocking down" a gene called transcriptional coactivator PPARg coactivator-1b (PGC-1b) can protect mice on a diet loaded with high-fructose from insulin resistance.
Allis sequenced the DNA encoding this enzyme, he found it to be strikingly similar to a yeast protein, GCN5, a previously identified transcriptional coactivator, as shown by Dr.
The AHR/ARNT dimer and transcriptional coactivators
A signature motif in transcriptional coactivators mediates binding to nuclear receptors.
Overexpression of transcriptional coactivators also accompanies progression in some cases and facilitates the activity of AR (Comuzzi et al.
Thus, asparagine hydroxylation allows for complex formation between HIF-1[alpha] and the CREB-binding protein and p300 transcriptional coactivators that in this way also become involved in the transcriptional control of HIF-dependent responses (Freedman et al.
Recruitment of the NCoA/SRC1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex.

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