Previous research has shown that many of these genes are located near super enhancers, which bind to proteins called transcription factors
that stimulate the copying of nearby genes into RNA.
Adrian Woolfson, M.D., Ph.D., Sangamo's Executive VP of Research and Development, said: "Sangamo's engineered ZFP-TFs demonstrated a combination of high selectivity, genome-wide specificity, and long-term tolerability that we believe establishes a new benchmark for engineered transcription factors
. Overall, these data provide compelling preclinical evidence for the potential viability of Sangamo's ZFP-TF gene regulation platform as a novel disease modifying therapeutic approach for the treatment of Huntington's disease."
These proteins, or transcription factors
, produced from genes in an organism's DNA, regulate the process by which cells decide whether or not to initiate development.
decoys are short, synthetic double-stranded DNA oligonucleotides that bind to transcription factors
and prevent their interaction with the genome, effectively inhibiting a coordinated network of pathologic gene expression.
The Cincinnati Children's research team has discovered a new clue about how the virus does this, a process that involves tiny proteins called transcription factors
Scientists have created iPSCs not with transcription factors
, but by adding a cocktail of chemicals to the cells.
Eighteen transcription factors
(TF) and 887 target genes were predicted to a combined total of 887 TF-to-target pairs.
Rosengart, a team of researchers showed that administration of a cocktail made of transcription factors
Gata4, Mef2c and Tbx5 (GMT) resulted in less scar tissue, or fibrosis, and up to a 50 percent increase in cardiac function in small animal models of the disease.
In (http://science.sciencemag.org/content/356/6337/eaaj2239) a new study published in the journal Science, a team of researchers has described how DNA-binding proteins (called transcription factors
) react to and interpret these "epigenetic" changes.
The developmental transcription factor
, Kriippel-like factor 7, was highly expressed within 60 min, and stress-related transcription factors
such as Elk-3 were highly expressed starting at 240 min.
Up to now, only mutations in the thyroid transcription factors
, such as PAX8, TTF1, NKX2-5, TTF2, and TSHR were associated with TD.