(redirected from transcription factor p65)


A gene on chromosome 11q13 that encodes a protein that binds to NFKB1 or NFKB2 to form the NFKB complex (the most abundant form is NFKB1/RELA), which is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); NFKBIA or NFKBIB inactivate the NFKB complex by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB)
marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.


Carisoprodol & meprobamate
References in periodicals archive ?
10] (PM [less than or equal to] 10 [micro]m in aerodynamic diameter) is mediated through an NF-[kappa]B dependent signaling mechanism that occurs through a pathway involving direct phosphorylation of the transcription factor p65 in the absence of I[kappa]B[alpha] degradation.

Full browser ?