SPI1

(redirected from transcription factor PU.1)

SPI1

A gene on chromosome 11p11.2 that encodes a transcription protein that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') which can act as a lymphoid-specific enhancer. SPI1 may be involved in the differentiation or activation of macrophages or B-cells; it binds RNA and may modulate pre-mRNA splicing.
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References in periodicals archive ?
There were no differences in the frequencies of Th9 in the ACS patients and in the control group patients, but its transcription factor PU.1 expression and functional cytokine IL-9 levels were significantly increased in patients with ACS.
Torbett,"Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells," The Journal of Immunology, vol.164, no.
Goswami et al., "The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation," Nature Immunology, vol.
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