GATA3

(redirected from transcription factor GATA-3)

GATA3

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the GATA family of transcription factors, which is a key regulator of T-cell development and plays an important role in endothelial cell biology.

Molecular pathology
GATA3 mutations cause hypoparathyroidism with sensorineural deafness and renal dysplasia.
References in periodicals archive ?
Objective: The aim of this proposal is to engineer biocompatible nanoparticles that deliver short interfering RNA (siRNA) to activated T cells (ATCs) for the downregulation of the Type 2 T helper cell (Th2) transcription factor GATA-3.
The cells were positive for cytokeratin (CK) 7, estrogen receptor (ER; 40%), BRST-2/GCDFP-15 (gross cystic disease fluid protein-15), mammoglobin, and the transcription factor GATA-3 (trans-acting T-cell--specific transcription factor GATA-3).
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