TFEB

(redirected from transcription factor EB)

TFEB

A gene on chromosome 6p21 that encodes a transcription factor which specifically recognises and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerisation of TFEB with itself or with another MiT/TFE family member (e.g., TFE3 or MITF); in association with TFE3, TFEB activates CD40L expression in T cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T cells and thymus-dependent humoral immunity.
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The seventh article recommends, when possible, a panel of cytokeratin (CK) 7, carbonic anhydrase IX (CA IX), CD117, human melanoma black 45 (HMB-45), [alpha]-methylacyl coenzyme A racemase (AMACR), and transcription factor E3 and transcription factor EB (TFE3/TFEB) for classifying renal epithelial tumors; CK20, p53, and CD44 for bladder urothelial carcinoma versus reactive urothelium; p63, NKX 3.
Preliminary results suggest that Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, lysosomal exocytosis and autophagy induction, also controls the expression of various exosome-associated genes.
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