The transcription factor E2F
promotes it, the inhibitory factors pRB and pRBp inhibit its transcription, and cyclin D can activates the cycle protein-dependent enzyme Cdk4-6, and then the active complex in the cell cycle plays the primary role of pRB phosphorylation into pRBp.
Other subjects include computational methods for protein structural class prediction, fundamentals of natural computation in living systems, and combining computational and experimental analysis for the prediction of transcription factor E2F
regulatory elements in the human gene promoter.
From the beginning of the mesh between ligands and receptors to the production of different responsive molecular proteins into cytoplasm and blood, MIF always emerges as a regulator via interacting with most of them, such as TLR4, cytoplasmic phospholipase [A.sub.2] ([cPLA.sub.2]), extracellular signal-regulated protein kinase (Erk), mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), transcription factor E2F
, inhibitory factor kinase1/2/3 (IKK1/2/3), activator protein-1 (AP1), transcription factor Sp1 and NF-[kappa]B, and the serine/threonine protein kinase (Akt).
Implication of transcription factor E2F
in regulation of DNA replication.
Mantle cell lymphoma (MCL), contrary to other types of small B-cell lymphomas, behaves in a clinically aggressive manner with a median survival of less than 4 years. Up to 70% of MCLs have the t(11;14) translocation involving the cyclin D1 gene at chromosome 11q13, which leads to overexpression of this gene.[2,3] However, cyclin D1 overexpression also occurs in MCLs that lack this translocation. Along with CDK4, cyclin D1 induces cell cycle progression through phosphorylation of the retinoblastoma (Rb) protein, which in turn releases the normally bound transcription factor E2F
. This important transcription factor then binds to promoters of genes that are critical to DNA synthesis and cell growth, such as the DNA polymerase [Alpha] gene, N-myc, c-myc, and the IGF-1 gene.[5-8]