E2F1

(redirected from transcription factor E2F)

E2F1

A gene on chromosome 20q11.2 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2Fs are targets of transforming proteins of small DNA tumour viruses.
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Other subjects include computational methods for protein structural class prediction, fundamentals of natural computation in living systems, and combining computational and experimental analysis for the prediction of transcription factor E2F regulatory elements in the human gene promoter.
2]), extracellular signal-regulated protein kinase (Erk), mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), transcription factor E2F, inhibitory factor kinase1/2/3 (IKK1/2/3), activator protein-1 (AP1), transcription factor Sp1 and NF-[kappa]B, and the serine/threonine protein kinase (Akt).
At the bottom of this pathway lie the functions of the transcription factor E2F, whose activity in the cell is regulated by the protein product of the retinoblastoma gene, Rb whose function is lost in about 40% of all human cancers.
A cDNA encoding a pBR-Binding protein with properties of the transcription factor E2F.

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