TCF7L2

(redirected from transcription factor 7-like 2)

TCF7L2

A gene on chromosome 10q25.3 that encodes a high mobility group (HMG)-box-containing transcription factor, which plays a key role in Wnt-signalling pathway, glucose homeostasis and key developmental and growth regulatory mechanisms of cells.

Molecular pathology
TCF7L2 mutation increases the risk of type-2 diabetes.
References in periodicals archive ?
of the CIBER Fisiopatologia de la Obesidad y Nutricion , the researchers focused on a variant in the Transcription Factor 7-Like 2 (TCF7L2) gene, which has been implicated in glucose metabolism but its relationship to cardiovascular disease risk has been uncertain.
the gene-encoding transcription factor 7-like 2 (TCF7L2), linked to type 2 diabetes;
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