TCF4

(redirected from transcription factor 4)

TCF4

A gene on chromosome 18q21.1 that encodes a basic helix-loop-helix (bHLH) transcription factor, which recognises an Ephrussi-box (E-box)-binding site first identified in immunoglobulin enhancers and expressed predominantly in pre-B-cells.

Molecular pathology
TCF4 mutations cause Pitt-Hopkins syndrome.
References in periodicals archive ?
In model systems, UPR is activated by a set of transcription factors including activating transcription factor 6 (ATF6 (N)), X-box binding protein 1 (XBP1), and activating transcription factor 4 (ATF4) (Walter and Ron, 2011).
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