transcriptase


Also found in: Dictionary, Thesaurus, Encyclopedia.

transcriptase

 [trans-krip´tās]
RNA polymerase; an enzyme that catalyzes the synthesis (polymerization) of RNA from ribonucleoside triphosphates, with DNA serving as a template.
reverse transcriptase see reverse transcriptase.

tran·scrip·tase

(tran-skrip'tās),
A polymerase associated with the process of transcription; may be RNA dependent or DNA dependent.
[L. transcribo, pp. transcriptum, to copy, + -ase]

transcriptase

/trans·crip·tase/ (-krip´tās) a DNA-directed RNA polymerase; an enzyme that catalyzes the synthesis (polymerization) of RNA from ribonucleoside triphosphates, with DNA serving as a template.
reverse transcriptase  see at R.

transcriptase

(trăn-skrĭp′tās, -tāz)
n.
1. A polymerase that catalyzes the formation of RNA from a DNA template in the process of transcription.
2. Reverse transcriptase.

transcriptase

[transkrip′tās]
an enzyme that induces transcription.

tran·scrip·tase

(tran-skrip'tās)
A polymerase associated with the process of transcription; especially the DNA-dependent RNA polymerase.
[L. transcribo, pp. transcriptum, to copy, + -ase]

transcriptase

Any enzyme that catalyses transcription of a molecule, as in the process of producing a copy of RNA from DNA. Reverse transcriptase is an enzyme found in viruses, such as HIV, that catalyses DNA from an RNA template-the reverse of the usual procedure.

transcriptase

an RNA POLYMERASE (either RNA- or DNA-dependent) involved in TRANSCRIPTION.

tran·scrip·tase

(tran-skrip'tās)
Polymerase associated with process of transcription; may be RNA or DNA dependent.
[L. transcribo, pp. transcriptum, to copy, + -ase]

transcriptase

RNA polymerase; an enzyme that catalyzes the synthesis (polymerization) of RNA from ribonucleoside triphosphates, with DNA serving as a template.

reverse transcriptase
RNA-directed DNA polymerase; an enzyme of retroviruses and hepadnaviruses that catalyzes the transcription of RNA to DNA.
viral transcriptase
see reverse transcriptase (above).
References in periodicals archive ?
WarmStart RTx Reverse Transcriptase builds upon NEB's portfolio of enzymes for nucleic acid detection, including Hot Start Taq DNA Polymerase, Q5 Hot Start High Fidelity DNA Polymerase, Bst 2.
The researchers used X-ray crystallography to describe in atomic detail how the AZT-resistance mutations allow reverse transcriptase to recruit ATP to remove the AZT.
Women given the intervention were 53% less likely than controls to have a mutation that conferred resistance to nonnucleoside reverse transcriptase inhibitors at 6 weeks after delivery.
This effect was not seen in patients who were not exposed to protease inhibitors and was not associated with exposure to non-nucleoside reverse transcriptase inhibitors, although patients were not exposed to this class of drug for as long.
nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), RNA polymerase inhibitors, integrase inhibitors.
Reverset is a nucleoside analog reverse transcriptase inhibitor that is being developed as a once-daily oral HIV therapy by Incyte Corporation and Pharmasset, Inc.
Even though other studies showed that elevations in triglyceride and cholesterol and body shape changes were also seen with the other classes of drugs and not just the protease inhibitors, the field had moved to using a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen as part of first-line therapy.
In a retrospective multicenter study of 201 patients, positive staining for human telomerase reverse transcriptase (hTERT) in the nucleolus was associated with a twofold higher relative risk of dying after curative resection for hepatic colorectal metastases; the increase was statistically significant (J.
NcRTIs -- Nucleotide-competitive Reverse Transcriptase Inhibitors
The development of protease inhibitor drugs last year - and the discovery that their potency was enhanced when combined with an earlier class of drugs called reverse transcriptase inhibitors - meant that for the first time since the epidemic exploded in the early 1980s, patients can dare to hope.
ATRIPLA contains 600 mg of efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate, both nucleoside reverse transcriptase inhibitors (NRTIs).
According to Chimerix deal, Merck will have to develope and commercialize CMX157, an investigational oral nucleoside reverse transcriptase inhibitor which is presently in Phase I clinical development.

Full browser ?