Inhibition of reverse transcriptase
remains the ideal way to combat this type of retrovirus by blocking the viral replication cycle.
campestris antiproliferative ([IC.sub.50]) lipid transfer protein ([mu]M) protein ([IC.sub.50]) ([IC.sub.50) ([mu]M) ([mu]M) HepG2 1 10 5.8 MCF-7 60 2 35 HT29 40 10 - HIV-1 0.23 - 4 reverse transcriptase
Asparagus DNase (Wang and Ng, 2001) and shallot antifungal protein (Wang and Ng, 2002) inhibit only one fungal species out of the several tested.
[1.] Use of nucleoside reverse transcriptase
inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration.
This effect was not seen in patients who were not exposed to protease inhibitors and was not associated with exposure to non-nucleoside reverse transcriptase
inhibitors, although patients were not exposed to this class of drug for as long.
nucleoside analogue reverse transcriptase
inhibitors (NRTIs), non-nucleoside reverse transcriptase
inhibitors (NNRTIs), RNA polymerase inhibitors, integrase inhibitors.
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase
inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
For the reverse transcription step (total volume of 10 [micro]L), the reaction mixture consisted of 1.5 mM Mg[Cl.sub.2] 2.5 [micro]M random hexamers, 25 U of Moloney murine leukemia virus reverse transcriptase
(Applied Biosystems), 10 units of RNase inhibitor, 1 mM 1,4-dithiothreitol, and 0.1 mM each of the deoxyribonucleoside triphosphates in 1 x GeneAmp PCR buffer II (Applied Biosystems).
Many people did not achieve durable virologic benefits from these drugs, mainly because they had previously taken and developed resistance to the nucleoside analog reverse transcriptase
* As an initial HIV treatment, the nucleoside reverse transcriptase
inhibitor ("nuke") Zerit (d4T) has been downgraded from a "preferred" HIV med to an "alternative" HIV med because of increasing reports of side effects, especially the association with lipoatrophy (fat wasting).
has granted a non-exclusive license to Procter & Gamble relating to Geron's human telomerase reverse transcriptase
(hTERT) technology for cell research applications.
(Gilead), based in California, is a nucleotide reverse transcriptase
inhibitor that works by blocking reverse transcriptase
, an enzyme that is involved in the replication of HIV, JT said in a press release.
In another type of test, RNA isolated from exposed cells was converted to cDNA and amplified by QRT-PCR (quantitative real-time reverse transcriptase
polymerase chain reaction) to quantify gene expression.