TCN2 encodes for transcobalamin
II which binds and transports vitamin B12 into the cell (Regec et al.
In the blood, transcobalamin
transport vitamin B12 to cells of the body[sup.
B12 deficiency are often due to TC II transcobalamin
transport protein, which is also caused by mercury, lead, antimony, and halogenated hydrocarbons such as PCB, PBB, DDT, and so on, that block methionine synthase enzyme.
Blood was collected at baseline for measurement of plasma vitamin B(12), transcobalamin
(TC), holotranscobalamin (holoTC), methylmalonic acid (MMA), total homocysteine (tHcy), and serum folate.
gene deletions/polymorphisms) and ASDs, including reduced folate carrier (RFC); catechol-O-methyltransferase (COMT); transcobalamin
II (TCN2); glutathione S-transferase M1 (GSTM1); glutathione S-transferase P1 (GSTP1); 5, 10-methylenetetrathydrofolate reductase (MTHFR); metal-regulatory transcription factor 1 (MTF1); and divalent metal ion transporter SLCllA3 (116, 114-117).
After three to four hours, the vitamin B12 appears in the blood carried on transcobalamin
The intrinsic-factor cobalamin complex enters the intestinal mucosal cells by receptor-mediated endoycytosis where cobalamin is released, which then binds to transcobalamin
Increased leucocyte alkaline phosphatase and transcobalamin
III in chronic myeloid leukaemia associated with lithium therapy.
12] is then transported in the circulation to the tissues bound predominantly to transcobalamin
The licensing agreement grants Kyto patent rights to the Transcobalamin
(Vitamin B12) Receptor and to an additional broad group of other patents which are critical to Kyto's research and development strategy for the treatment of cancer.
concentration is significantly increased in blacks (39)] as well as in response to acquired causes [e.
The author concluded that vitamin B12 dependency disorders are common and neglected by the medical profession because: (1) the body level of vitamin B12 needed for full biological efficiency is unknown; (2) patients might have a deficiency in transporting vitamin B12 into their tissues (low levels of transcobalamin
11); and (3) a large increase in a vitamin level might be needed to "force" one or more abnormal chemical reactions to proceed normally.