Human aquaporins: regulators of transcellular water
These proteins control water relations  and act as regulators of transcellular water flow .
Human aquaporins: regulators of transcellular water flow," Biochimica et Biophysica Acta, vol.
The main route of water exchange is via aquaporin(s) channels, which display an exquisite specificity for water; it is a fast-reacting system that allows water to import and export to the cells, and it also contributes to transcellular water flow (Carlsson et al.
In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats.
In addition to transcellular water transport across the plasma membrane of epithelial and endothelial barriers, AQPs have been implicated in cell migration, proliferation, and volume regulation (Verkman, 2011).
DRIP and PRIP at the apical and basal plasma membranes, respectively, act in concert to provide a major route for transcellular water movement in hindgut epithelial cells.
Transcellular water transport may occur by simple diffusion through lipid bilayers or become markedly improved by the insertion of integral channel proteins (aquaporins) in the plasma membrane.
Discovery and Structure of Aquaporins and the Basis for Transcellular Water Flow
In zebrafish larvae, Aqplal was localized in the basolateral membrane of ionocytes of the yolk sac skin, where they were assigned a role in transcellular water transport (Kwong et al.
The Aqp1aa protein was localized in the apical brush-border membrane in the intestinal epithelium in several SW-acclimated fish species, suggesting an entry pathway for transcellular water transport (Aoki et al.
Aquaporin 7 (Aqp7) is found apically in the mammalian gastrointestinal tract, where it is assigned a role in transcellular water transport (Laforenza et al.