Cells from the hepatobiliary tract including hepatocytes, cholangiocytes, gallbladder epithelial cells, and endothelial cells from blood vessels have indeed been shown to express various AQPs that could account for transcellular
water transport (Masyuk & LaRusso, 2006; Portincasa & Calamita, 2012; Gregoire et al., 2015).
This suggested the accumulation of water in the transcellular
space of digestive tract .
Pulmonary edema is caused by AQP 5 by reducing the transcellular
rate of the removal of excess water, which then infiltrates alveolar and interstitial spaces (7).
Whereas drugs enter sebum via transcellular
and intercellular diffusion, they enter sweat by passive diffusion from the bloodstream into the sweat glands and tend to accumulate because of an ion-trapping phenomenon when basic drugs are concerned, owing to their ionization at the lower pH ofsweat.
Nitric oxide: a novel signal transduction mechanism for transcellular
This thin but effective barrier expresses tight intercellular connections and protects the body from outer stimuli, e.g., inhaled toxins, particles and microorganisms (Crandall and Matthay, 2001); moreover it also allows transcellular
transport of solutes and gases by passive diffusion or active transport (Endter et al., 2009).
Lactulose and mannitol are both poorly absorbed, nondigestible carbohydrates, and an elevated ratio indicates either increased intestinal permeability to large molecules between the intestinal epithelial cells (lactulose) or decreased transcellular
absorption (mannitol), reflecting a loss of absorptive surface area .
This presented intercellular openings, transcellular
holes, and endothelial fenestrae.
For this reason, Caco-2 cells have been found to be an excellent model for passive transcellular
transport normally occurring in vivo  and to investigate intestinal barrier permeability in steatohepatitis .
Lipophilic drugs are thought to be rapidly absorbed after dissolution by passive transcellular
diffusion through epithelial cells .
Food and nutrients are absorbed into enterocytes and later the capillaries via transcellular
and paracellular transport.
Thyrotoxic periodic paralysis is not a condition of net potassium deficiency; rather it is a condition of transcellular
shift of potassium [4,7].