Concerns that subsequently arose regarding a potential adverse impact on breast cancer risk and the growth of existing estrogen dependent tumours were predominantly triggered by findings from in vitro research as well as rodent studies showing that isoflavones bind to and transactivate
estrogen receptors (ERs) (Jefferson 2000, Muthyala 2004) and induce proliferation and estrogenic markers in MCF-7 cells (an ER positive breast cancer cell line) (Bodinet 2004, Ju 2001, Schmidt 2001).
Activating SMYD3 transactivates
a set of genes associated with cell-cycle regulation, and this leads to the acceleration of cancer cell growth.
A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates
To date, experiments in vitro have shown no evidence that TRIOLEX directly binds and/or transactivates
the PPAR-gamma receptor.
The RB protein is phosphorylated by cyclin D-CDK4/6, and is then separated from E2F, which transactivates
genes necessary for the [G.
As a result, the HIF1A is stabilized and transactivates
In response to diverse cellular stresses, p53 protein transactivates
downstream target genes required for DNA repair, cell cycle arrest, and apoptosis (Pietsch et al.
2 translocation RCCs transactivates
the MET promoter in vitro and, hence, increasing MET mRNA and protein expression.
Extracellular calcium-sensing receptor transactivates
the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism.
Prostaglandin E2 transactivates
EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
50) Thereafter the complex translocates to the nucleus where SMAD4 acts as a transcription factor and transactivates
target genes involved in growth inhibition and apoptosis.
Similarly to hypoxia, Ni(II) exposure upregulates HIF-1 and transactivates
HIF-1-dependent genes that are critical for invasion and metastasis that can be facilitated by the impairment of ECM.