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Formation of spliced products containing portions of two different transcripts.
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These polycistronic RNAs are ultimately processed into individual molecules through the addition of a Spliced Leader [SL], a common miniexon sequence present in all the mature mRNAs of trypanosomatids, to the 5' end and a poly [A] tail to the 3' end, processes known as trans-splicing and polyadenylation, respectively [8].
In trypanosomatids, it has also been demonstrated the existence of alternative trans-splicing in which two or more mature transcripts are generated from the same gene by the use of different trans-splicing acceptor sites.
In this work, was carried out a detailed characterization of the 5' and 3' UTRs of the LYT1 mRNAs, as a first step of a project aimed to the identification of RBPs implicated in the modulation of both their expression and alternative trans-splicing rates.
cruzi CL Brener strain are generated in vivo by alternative trans-splicing, giving rise to three transcripts differing in their 5' UTRs [15].
Intergenically spliced chimeric RNAs have been shown to occur via cis-splicing of adjacent genes (cis-SAGe) as well as long-range intrachromosomal and interchromosomal trans-splicing events [3, 5, 6].
Further characterization of SLC45A3ELK4 chimeras showed that the transcript was created through cis-SAGe rather than trans-splicing [24], and most notably the exon 1/exon 2 form of the chimera functions as an androgen-responsive chimeric long noncoding RNA [25] (Figure 1(a)).
As chimeric trans-splicing requires both parental transcripts to be present, it is likely that these events may be dependent upon the spatial proximity of the parental genes.
Lin, "Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors," FEBS Letters, vol.
However, due to a nematode-specific RNA trans-splicing mechanism, affecting post-transcriptional gene regulation, the relevance of these results to others organisms remains unclear.
Among the topics are yeast-based chemical genomic approaches, activity-based protein profiling of cys proteases, using analogue sensitive technologies to target kinases of interest, using split inteins to prepare semi-synthetic proteins and to study the mechanisms of protein trans-splicing, and introducing chemical reporter groups by bio-orthogonal ligation reactions for imaging cell-surface glycans.
A trans-splicing group I intron and tRNA-hyperediting in the mitochondrial genome of the lycophyte Isoetes engelmannii.
A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention.
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