trace amines

trace amines

A generic term for biogenic amines which are present in very low amounts in mammalian tissues. While some trace amines act as neurotransmitters in invertebrates, the extent to which they act as such in vertebrates is speculative; they are likely involved in various physiological functions.

Examples
Beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine.
References in periodicals archive ?
23) Tyramine enters the cell via NET, where it interacts with TAAR1, a G protein-coupled receptor that is responsive to trace amines, such as tyramine, as well as amphetamines.
Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications.
TR 1 is a novel receptor in the brain that is activated by minute amounts of brain chemicals called trace amines.
Jun-Xu Li, MD, PhD, senior author and assistant professor of pharmacology and toxicology in the UB School of Medicine and Biomedical Sciences, said that their research shows that trace amine associated receptor 1 - TR 1 - holds great promise as a novel drug target for the development of novel medications for cocaine addiction.
Obscure chemicals called trace amines have receptors on brain cells and may play a role in depression and schizophrenia (160: 37).
Your story on trace amines in the brain ("Obscure brain chemicals draw new attention," SN: 7/21/01, p.
In comparison, the chemicals called trace amines are considered mere bit players.
The low concentrations of trace amines and their rapid turnover in the brain also made them difficult to study.
The trace amines, which include tyramine, beta-phenylethylamine (beta-PEA), tryptamine, and octopamine, continued to draw some attention.
Although still speculative, the link between mental illness and trace amines has several lines of evidence supporting it.
As for schizophrenia, a surplus of trace amines may be part of the problem.
A recent study in fruit flies implicated one of the trace amines in the insect's response to cocaine, for example.