Jun-Xu Li, MD, PhD, senior author and assistant professor of pharmacology and toxicology in the UB School of Medicine and Biomedical Sciences, said that their research shows that trace amine associated receptor 1 - TR 1 - holds great promise as a novel drug target for the development of novel medications for cocaine addiction.
TR 1 is a novel receptor in the brain that is activated by minute amounts of brain chemicals called trace amines.
For example, our depression, metabolic diseases, trace amine
and our Neuropeptide FF programs all have come from our SNAP Discovery platform.
Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications.
Trace amines: identification of a family of mammalian G protein coupled receptors.
* Obscure chemicals called trace amines
have receptors on brain cells and may play a role in depression and schizophrenia (160: 37).
Your story on trace amines
in the brain ("Obscure brain chemicals draw new attention," SN: 7/21/01, p.
In comparison, the chemicals called trace amines are considered mere bit players.
Trace amines, so-named because they're present at low concentrations in the human brain, drew considerable interest in the 1960s.
The trace amines, which include tyramine, beta-phenylethylamine (beta-PEA), tryptamine, and octopamine, continued to draw some attention.
Although still speculative, the link between mental illness and trace amines has several lines of evidence supporting it.
As for schizophrenia, a surplus of trace amines may be part of the problem.