Merkel cell carcinoma

(redirected from trabecular carcinoma of the skin)

Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Trabecular carcinoma of the skin. Arch Dermatol 1972; 105(1):107-110.
In 1972, Toker first described a trabecular carcinoma of the skin [7].
Therefore, throughout the last decades Merkel cell carcinoma has been described under trabecular carcinoma of the skin, cutaneous neuroendocrine carcinoma, and Merkel cell carcinoma.
Trabecular carcinoma of the skin: An ultrastructural study.
Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study.
In 1972, Toker described an unknown, trabecular carcinoma of the skin in five caucasian patients [3].