Urine samples were also collected from 30 of these 100 patients for the quantification of Tr-DNA (mean, 7 samples/patient).
tCF-DNA and Tr-DNA were quantified by real-time PCR amplification of the HBB gene in an ABI Prism 7000 Sequence Detection System (Applied Biosystems).
Using a new proprietary method for isolation of Tr-DNA, Xenomics' scientists successfully detected sequences of a single copy Y chromosome-specific SRY gene in urine of women pregnant with male fetuses from the 6th week of pregnancy.
Since use of Tr-DNA for molecular diagnostics is a platform technology, success in one area based on significant improvements of Tr-DNA isolation and detection methodologies will accelerate test development in other fields including oncology, infectious diseases, and transplantation.
Using this new approach, Xenomics is planning to develop kits for research use to accelerate the application of its proprietary Tr-DNA technology in different areas of DNA-based molecular diagnostics, in both humans as well as animals.
The method is simple, cost-effective, applicable to small and large volumes of urine, and can be used for Tr-DNA preservation, storage, shipping and purification.
Through the analysis of easily obtained small urine specimens, these Tr-DNA
fragments provide current and vital information about a wide range of conditions inside the body, including serious infectious diseases.
a collaborative venture between Xenomics and Italy's National Institute for Infectious Diseases "Lazzaro Spallanzani" (INMI), will lead an international consortium focusing on the development of a diagnostic test for tuberculosis utilizing Xenomics' Tr-DNA technology.
Through the analysis of easily obtained urine samples, these Tr-DNA fragments provide immediate and vital information about a wide range of conditions inside the body, including serious infectious diseases.
Currently, Xenomics is focusing on implementation of its urinary DNA-based test for high-risk Human Papilloma Virus (HPV) and development of other tests based on Tr-DNA
These results were obtained when new proprietary methods of Tr-DNA
isolation and analysis were applied for prenatal testing.
Currently, Xenomics is focusing on implementation of its urinary DNA-based test for high-risk HPV and development of other tests based on Tr-DNA