toxoid


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Related to toxoid: tetanus toxoid, diphtheria toxoid

toxoid

 [tok´soid]
a toxin treated by heat or chemical agent to destroy its deleterious properties without destroying its ability to combine with or stimulate the formation of antitoxin.
diphtheria toxoid a sterile preparation of formaldehyde-treated products of the growth of Corynebacterium diphtheriae, used as an active immunizing agent, generally in mixtures with tetanus toxoid and pertussis vaccine (DTP) or with tetanus toxoid alone (DT for pediatric use and Td, which contains less diphtheria toxoid, for adult use).
tetanus toxoid a sterile preparation of formaldehyde-treated products of the growth of Clostridium tetani, used as an active immunizing agent, either in mixtures with diphtheria toxoid and pertussis vaccine (DTP, DT, Td) or by itself (T).
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

tox·oid

(tok'soyd),
A toxin that has been treated (commonly with formaldehyde) so as to destroy its toxic property but retain its antigenicity, that is, its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity. For specific toxoids, see entries under vaccine
Synonym(s): anatoxin
[toxin + G. eidos, resemblance]
Farlex Partner Medical Dictionary © Farlex 2012

toxoid

(tŏk′soid′)
n.
A substance that has been treated to destroy its toxic properties but retains the capacity to stimulate production of antitoxins, used in immunization.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

toxoid

Immunology A bacterial toxin or other antigen treated with formaldehyde to ↓ toxicity while preserving antigenicity; toxoids are used to prepare diphtheria and tetanus vaccines. Cf Freund's adjuvant.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

tox·oid

(tok'soyd)
A toxin that has been treated (commonly with formaldehyde) so as to destroy its toxic property but retain its antigenicity, i.e., its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity.
[toxin + G. eidos, resemblance]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

toxoid

A bacterial toxin that has been chemically changed so as to lose its poisonous properties but retain its ability to stimulate antibody production. Toxoids make excellent vaccines against infections characterized by exotoxin production, such as DIPHTHERIA and TETANUS.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

toxoid

a substance produced from a toxin but in which the toxicity is destroyed while the property of inducing immunity to the toxin is retained. Used to immunize against toxigenic infections, for example DIPHTHERIA and TETANUS.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Toxoid

A preparation made from inactivated exotoxin, used in immunization.
Mentioned in: Diphtheria
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

tox·oid

(tok'soyd)
Toxin that has been treated (commonly with formaldehyde) to destroy its toxic property but retain its antigenicity, i.e., its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity.
[toxin + G. eidos, resemblance]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
TABLE 2 Tetanus prophylaxis in wound management (ages 19-64 years) CLEAN MINOR WOUND ALL OTHER WOUNDS * HISTORY OF ADSORBED TDAP OR TD TDAP OR TD TETANUS TOXOID ([dagger]) TIG ([dagger]) TIG Unknown or <3 Yes No Yes Yes [greater than or equal to]3 No ([double No No ** No dagger]) * Such as, but not limited to, wounds contaminated with dirt, feces, soil, and saliva; puncture wounds; avulsions; and wounds resulting from missiles, crushing, burns, and frosbite.
For each study group, Hiberix was coadministered with recommended routine childhood vaccines (Pediarix [diphtheria and tetanus toxoids and acellular pertussis (DTaP)/ hepatitis B (HepB)/inactivated poliovirus (IPV)]; Prevnar13 [Pneumococcal 13-valent Conjugate Vaccine], and Rotarix [Rotavirus Vaccine, Live, Oral Suspension]), and noninferiority of immune responses to antigens contained in the coadministered vaccines, with the exception of Rotarix, was assessed.
On March 24, 2015, the Food and Drug Administration licensed an additional combined diphtheria and tetanus toxoids and acellular pertussis adsorbed (DTaP) and inactivated poliovirus (IPV) vaccine (DTaP-IPV) (Quadracel, Sanofi Pasteur Inc.).
Both vaccines contain diphtheria toxoid. Here, concerns about increased local reactions are largely theoretical but data are limited, Dr.
therapeutic TIG received 1 5,000 Survived 2 5,000 Died 3 1,000 Died 4 250 Died 5 500 Survived 6 Unknown Survived 7 Unknown Survived 8 3,000 Died 9 5,000 Died Abbreviations: TT = tetanus toxoid; TIG = tetanus immune globulin; N/A = not applicable.
Arthus reactions and whole limb swelling are hypersensitivity reactions that have been associated with vaccines containing tetanus toxoid, tetanus and diphtheria toxoids, and/or pertussis antigens.
However, another study suggested that Td which contains about the same amounts of tetanus and diphtheria toxoid as does Tdap--can be administered safely 1 month before meningococcal polysaccharide-protein conjugate vaccine, Dr.
In a pivotal clinical study of 4,114 healthy 10-18 year olds, Boostrix (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine adsorbed [Tdap]) was comparable in both immunogenicity and safety with a currently licensed tetanus-diphtheria toxoid(Td) vaccine and produced antibody responses at least as high as those seen in infants who receive the current higher-antigen DTaP vaccine, said Dr.
That footnote should read, "[paragraph] Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine on or after age 10 years."