toxicokinetics


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toxicokinetics

The study of the absorption, distribution, metabolism, and elimination of hazardous substances by an organism.
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References in periodicals archive ?
Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): Influence of physico-chemical properties and of biological processes.
Unfortunately, full mathematical representation of ANN and SVM models was not present in any of the evaluated articles reporting toxicokinetics endpoints.
The main goal of the present work was to investigate the bioconcentration and toxicokinetics of MC-LR in the gills of the two marine bivalves exposed to different MC-LR concentrations.
However, further studies evaluating the transplant of animals for a longer period are needed for a better understanding of Hg toxicokinetics in coastal environments.
Due to the toxicokinetics and toxicodynamics of the toxic agents involved, exposure to organic solvents can trigger different behavioral and neurophysiological responses depending on gender (14).
Toxicokinetics studies were processed by DAS 2.1.1 software package (Chinese Pharmacological Society) to calculate half-life ([T.sub.1/2]), the maximum plasma concentration ([C.sub.max]), the corresponding time ([T.sub.max]), and the area under concentrationtime curve (AUC).
Loperamide toxicokinetics: serum concentrations in the overdose setting.
In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity.
Toxicological study design considerations include species selection (default to rat and dog) and pharmacological considerations, compound metabolic/PK profile; testing of the quality of the drug candidate; formulation; dose-exposure linearity information; study duration; clinical endpoints (clinical observations, body weight, food consumption); pathology endpoints (clinical pathology and gross and histopathology) and toxicokinetics.
Early chapters examine molecular and cellular toxicology, covering topics on measuring toxicity and assessing risk; toxicokinetics, which is the phase of poisoning in which the poison undergoes movement within the body; biotransformation; cellular sites of action; genomics; and carcinogenesis.
The modeling topic of ENTOX mainly comprise (a) identification of the pathogen-pollutants and toxic stressor-effect relationship; (b) fate, behavior and transport of organic/non-organic toxic compounds degradation in exposure medium [2-4]; (c) absorption, distribution, metabolism and excretion of environmental contaminants within exposure sentinel species, human and animal [5-7]; (d) toxicokinetics (TK) and toxicodynamics (TD) mechanism at target sites [8]; and (e) risk assessment of toxic pollutant propagation from organisms to populations and variations in ecosystem sensitivities under various scenarios [5,9].