toxicogenomics


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toxicogenomics

analysing the toxicity of substances by applying the whole genome approach. This field is based on the premise that responses to TOXIC chemicals have their origin in GENE EXPRESSION. Determining how genes respond to toxicants could provide a direct measure of their toxicity. DNA MICROARRAYS/CHIPS are central to this, since they enable the expression of thousands of genes to be monitored simultaneously and a specific gene expression profile to be generated for each toxin.
References in periodicals archive ?
The 14 chapters grew out of a symposium at the Environmental Mutagenesis and Genomics Society's September 2014 meeting in Orlando, Florida, where many of the chapter authors presented papers on toxicogenomics and risk assessment.
Permanent links to the National Library of Medicine (NLM) TOXNET records are now provided for the Hazardous Substances Data Bank (HSDB), TOXLINE, LactMed, Developmental and Reproductive Toxicology Database (DART), Toxics Release Inventory (TRI), Comparative Toxicogenomics Database (CTD), Integrated Risk Information System (IRIS), International Toxicity Estimates for Risk (ITER), Chemical Carcinogenesis Research Information System (CCRIS), and GENE-TOX.
To identify associated dysfunctions and diseases, they integrated protein-disease annotations into the protein complexes using the Online Mendelian Inheritance in Man database and the Comparative Toxicogenomics Database.
Applications of toxicogenomics in safety evaluation and risk assessment.
Their areas of expertise are toxicogenomics, pharmacogenomics and oncology.
Topics include: analysis and interpretation of toxicogenomic data, principles of data mining, study design issues, sources of variability in toxicogenomic assays, toxicogenomics as a tool to assess immunotoxicity, and potential uses of toxicogenomic biomarkers in occupational health and risk assessment.
Toxicogenomics and ecotoxicogenomics for studying endocrine disruption and basic biology.
A new report issued today by the National Academies of Sciences (NAS) recognizes the importance of toxicogenomics in predicting effects on human health and recommends the integration of toxicogenomics into regulatory decision making.
Collaborative research in various fields of medicine has led to the creation of new disciplines such as pharmacogenomics and toxicogenomics.
scientists at Paradigm Genetics are building a database of toxicogenomics studies.
CuraGen scientists will apply the company's Predictive Toxicogenomics Screen and protein pathway mapping technologies to gain a better understanding of the mechanisms that enable drugs to effectively treat certain diseases.