toxicogenomics


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toxicogenomics

analysing the toxicity of substances by applying the whole genome approach. This field is based on the premise that responses to TOXIC chemicals have their origin in GENE EXPRESSION. Determining how genes respond to toxicants could provide a direct measure of their toxicity. DNA MICROARRAYS/CHIPS are central to this, since they enable the expression of thousands of genes to be monitored simultaneously and a specific gene expression profile to be generated for each toxin.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Albert Braeuning, a toxicogenomics expert at the German Institute for Risk Assessment (BfR), has been analyzing the effect of microplastic on mice.
Since its release in 2004, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org) has evolved into a premier resource that integrates manually curated data on toxicogenomic interactions among chemicals, genes, phenotypes, diseases, and pathways (Davis et al.
The 14 chapters grew out of a symposium at the Environmental Mutagenesis and Genomics Society's September 2014 meeting in Orlando, Florida, where many of the chapter authors presented papers on toxicogenomics and risk assessment.
The terms toxicogenomics and pharmacogenomics are presented and how they are associated with metabolomics and the value of systems biology and systems toxicology.
Mattingly, "Text mining and manual curation of chemical-gene-disease networks for the Comparative Toxicogenomics Database (CTD)," BMC Bioinformatics, vol.
Compiled and presented by Se-Kown Kim (Distnguished Professor in the Department of Marine Bio Covergence Science and Technology and Director of Marine Bioprocess Research Center at Pukyong National university, Busan, South Korea), "Marine Omics: Principles and Applications" provides comprehensive coverage on current trends in marine omics of various relevant topics such as genomics, lipidomics, proteomics, foodomics, transcriptomics, metabolomics, nutrigenomics, pharmacogenomics and toxicogenomics as related to and applied to marine biotechnology, molecular biology, marine biology, marine microbiology, environmental biotechnology, environmental science, aquaculture, pharmaceutical science and bioprocess engineering.
Permanent links to the National Library of Medicine (NLM) TOXNET records are now provided for the Hazardous Substances Data Bank (HSDB), TOXLINE, LactMed, Developmental and Reproductive Toxicology Database (DART), Toxics Release Inventory (TRI), Comparative Toxicogenomics Database (CTD), Integrated Risk Information System (IRIS), International Toxicity Estimates for Risk (ITER), Chemical Carcinogenesis Research Information System (CCRIS), and GENE-TOX.
They begin with concepts in drug development--its stages, nonclinical safety evaluation, toxicokinetics, toxicologic pathology and routine and special techniques, principles of clinical pathology, toxicogenomics, and spontaneous lesions in control animals used in toxicity studies--then address pathological changes related to toxicity in each organ system, and their implications in the drug development process.
Chapter highlights include absorption, distribution, metabolism, excretion (ADME), acute sub-chronic and chronic toxicity testing, toxicogenomics, developmental and reproductive toxicology, carcinogenicity testing, histopathology, imaging, immunotoxicity.
9 a.m.: Cross-Species Analysis of Toxicogenomics Data: Approaches for Assessing Differences in Sensitivity and Conservation of Mode of Action