toxicodynamics

toxicodynamics

(tok″sĭ-kō-dī-nam′iks) [ toxico- + dynamics]
The processes that affect the uptake of, metabolism by, damage to, and disposal of a poison by an organism.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Toxicodynamics of Lead, Cadmium, Mercury and Arsenicinduced kidney toxicity and treatment strategy: a mini review.
In vitro cytotoxicity tests are prerequisites for describing intrinsic toxicodynamics of phytochemicals in any potential medicinal plant (Sutar et al.
A better understanding of mechanistic toxicokinetics and toxicodynamics (TKTD) relationships in combination with pharmacokinetics and pharmacodynamics (PKPD) should establish improved quantitative monitoring of safety margins in non-clinical and clinical research.
Additionally, it is important to take into account the mixture accumulation by its toxicokinetics and its toxicodynamics which is related to the receptor interactions and the chemical interactions.
In particular, future cooperative actions may focus on information availability and accessibility with regard to: a) substance identities and compositions in products, including polymeric PFASs; b) production, use, and disposal volumes of individual PFASs; c) experimental data on physicochemical properties; d) toxic effects of individual PFASs, in particular the so-far-overlooked PFASs, including a mechanistic understanding of their toxicokinetics and toxicodynamics and of their effects in humans and on the ecosystem level; and e) the life cycle of polymeric PFASs.
Pyrethroid stereoisomerism is an important characteristic that must be considered in the analysis of these compounds in environmental matrices, since they present enantiomeric selectivity in the biogeochemical cycle, toxicokinetic and toxicodynamics. Studies have shown that the induction of toxic effects are derived from distinct enantiomers that those causing potential estrogenic effects.
Due to the toxicokinetics and toxicodynamics of the toxic agents involved, exposure to organic solvents can trigger different behavioral and neurophysiological responses depending on gender (14).
The sensitivity of hair cells to the toxicity of solvents can be explained by toxicokinetics and toxicodynamics, since these cells are sensory cells, with high levels of lipids and the solvents are liposoluble [32].
Toxicokinetics and toxicodynamics of ochratoxin A an update.
At the municipal level, environmental contamination and human poisoning estimates may be inferred according to the type of predominant crop in the municipality, the types of pesticides used and their toxicological characteristics (such as toxicodynamics and toxicokinetics), serving as a warning to health professionals to subsidize Health Surveillance actions.