Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to toxic jaundice: prehepatic jaundice
Jaundice resulting from chemical injury to the liver or sepsis.
See also: jaundice
yellowness of skin, sclerae, mucous membranes, and excretions due to hyperbilirubinemia and deposition of bile pigments. Called also icterus. It is usually first noticeable in the sclera.
The pigment causing jaundice is called bilirubin. It is derived from hemoglobin that is released when erythrocytes are hemolyzed and therefore is constantly being formed and introduced into the blood as worn-out or defective erythrocytes are destroyed by the body. Normally the liver cells absorb the bilirubin and secrete it along with other bile constituents. If the liver is diseased, or if the flow of bile is obstructed, or if destruction of erythrocytes is excessive, the bilirubin accumulates in the blood and eventually will produce jaundice. Determination of the level of bilirubin in the blood is of value in detecting elevated bilirubin levels at the earliest stages before jaundice appears, when liver disease or hemolytic anemia is suspected.
jaundice without bilirubinemia, associated with elevated unconjugated bilirubin that is not excreted by the kidney.
that resulting from abnormality of bile flow in the liver.
jaundice associated with hemolytic anemia in which most of the bilirubin is unconjugated. Called also retention jaundice, prehepatic jaundice.
jaundice caused by injury to or disease of the liver cells.
see icteric index.
that due to an abnormality in bilirubin metabolism.
that due to blockage of the flow of bile, resulting in conjugated hyperbilirubinemia. Called also regurgitation jaundice.
mild icterus neonatorum during the first few days after birth.
obstructive jaundice (above).
see hepatocellular jaundice (above).