After these patients received total-body irradiation
to destroy their own HSCs, they received donor HSCs from relatives or strangers.
of animals leads to multiple organ dysfunctions due to gastrointestinal, cerebrovascular, or hematopoietic system toxicity.
High-dose fractionated total-body irradiation
, etoposide and cyclophosphamide for treatment of malignant lymphoma: comparison of autologous bone marrow and peripheral blood stem cells.
. A [sup.60]Co irradiator was used for total-body ionizing irradiation.
The authors used in their analyses the doubly weighted (via radiation and tissue weighting factors) hypothetical effective dose rate and effective dose related to total-body irradiation
from sources outside the body.
Three analyses calculated the relative risk of BCC in patients who received radiation for tinea capitis or who underwent total-body irradiation
before hematopoietic cell transplantation, they said.
Felgyinszki et al., "Effects of low-dose radiation on the immune system of mice after total-body irradiation
," Radiation Research, vol.
For example, when tumor cells are transplanted into the groins of mice, the rate of their metastasis into the lung is cut about in half by total-body irradiation
with 15-30 cGy 12 days after the transplantation.
Patients in the palifermin group received the FDA-approved dosing schedule, which consisted of an intravenous injection bolus of 60 mcg/kg per day for 3 days prior to total-body irradiation
and chemotherapy and then for 3 days at the same dose immediately after transplantation of peripheral-blood hematopoietic stem cells.
In this multicenter study, researchers evaluated the outcomes of 68 adults with life-threatening hematologic disorders treated with intensive chemotherapy or total-body irradiation
followed by HLA-mismatched umbilical cord blood transplants from unrelated donors (48 were mismatched for 2 or more HLA antigens).
Donnenberg and their colleagues at the Johns Hopkins Oncology Center in Baltimore exposed the patient to high-dose, total-body irradiation
and chemotherapy, killing every kind of blood- and bone-marrow-derived cell known to harbor HIV.
Levy et al., "Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation
and bone marrow transplantation," Blood, vol.