Muluye, "Total lymphocyte count
as surrogate marker for CD4 cell count in HIV-infected individuals in Gondar University Hospital, Northwest Ethiopia," AIDS Research and Therapy, vol.
Caption: Figure 3: Scatter plots depicting the correlations of CD4 count and total lymphocyte count
Flanigan et al., "Total lymphocyte count
(TLC) is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries," Journal of Acquired Immune Deficiency Syndromes, vol.
In this study, we are evaluating "Total Lymphocyte Count
, Haemoglobin level, Body Mass Index and serum Albumin as low cost surrogate markers for disease progression in HIV/AIDS."
In the training set, on univariate analysis, the following variables were associated with the presence of HIV co-infection at P<0.1 significance level: increasing age; male gender; lower body-mass index, mid-arm circumference, and triceps skinfold thickness; absence of pulmonary involvement, miliary disease, and cavity formation on chest radiograph; negative sputum-smear and tuberculin skin test status; presence of axillary, inguinal, mediastinal, and intra-abdominal lymphadenopathy, pleural effusion, and meningitis; and low levels of haemoglobin, total lymphocyte count
, and serum albumin (Table I).
The CD4+ T-lymphocyte % values were calculated by dividing the absolute CD4+ T-lymphocyte count with the total lymphocyte count
and multiplying by hundred.
Initial laboratory values at the referring hospital included the following: leukocyte count 3,300 cells/[mm.sup.3], total lymphocyte count
640 cells/[mm.sup.3], hemoglobin 13 g/dL, and platelet count 400,000 cells/[mm.sup.3].
* To determine whether the Total Lymphocyte Count
accurately predicts a low CD 4 count in HIV infected persons and its clinical correlation.
Laboratory examination of haematological, immunological and biochemical parameters revealed that the patient had a haemoglobin (Hb) of 11.8 g/dl (normal values 10-15 g/dl), erythrocyte sedimentation rate (ESR) of 57 mm (normal value 0-20 mm), total thrombocyte count of 243 x [10.sup.9]/1 (normal values 137367 x [10.sup.9]/1), total leucocyte count of 8.0 x [10.sup.9]/1 (normal values 3.9-9.4 x [10.sup.9]/1), and a high total lymphocyte count
(TLC) of 4.1 x [10.sup.9]/1 (normal values 1.2-3.4 x [10.sup.9]/1).