total iron-binding capacity


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total iron-binding capacity (TIBC),

an indirect method of determining the transferrin level in serum. Transferrin is saturated by the addition of iron to a serum specimen. Excess iron is removed, and the specimen is analyzed for iron content. The result is the total amount of iron that can be bound by transferrin. This result is helpful in differentiating anemias: high TIBC is associated with iron deficiency, low TIBC is associated with excess iron.

to·tal iron-bind·ing ca·pac·i·ty

(TIBC) (tō'tăl ī'ŏrn bīnd'ing kă-pas'i-tē)
An indirect method of determining the transferrin level in serum. Transferrin is saturated by the addition of iron to a serum specimen. Excess iron is removed, and the specimen is analyzed for iron content. The result is the total amount of iron that can be bound by transferrin. This result is helpful in differentiating anemias: high TIBC is associated with iron deficiency, low TIBC is associated with excess iron.
References in periodicals archive ?
Transferrin saturation is a function of the serum iron concentration divided by the total iron-binding capacity of the serum.
Iron-deficiency anemia should be suspected if the patient has a low serum ferritin, high total iron-binding capacity, low serum iron, and low transferrin saturation.
Initial laboratory tests for elevated AST/ALT should include a hepatitis B and C panel, iron and total iron-binding capacity, serum electrophoresis, and serum ceruplasmin.
Where the total iron-binding capacity (TIBC) = 25 x the Tf concentration, in g/L (15).
A test for iron, total iron-binding capacity, percentage saturation of iron-binding capacity, ferritin and soluble transferrin receptor levels will distinguish anemia of chronic disease (ACD) from iron-deficiency anemia (IDA).
Serum total iron, total iron-binding capacity (TIBC), unsaturated iron binding capacity (UIBC), and the percentage saturation of iron-binding capacity were determined by colorimetric assay (ferrozine method; Sigma Diagnostics) as described previously (7).
Low serum iron and ferritin, and high total iron-binding capacity.
Third, if the initial enzyme levels are more than two times the upper limit of normal, do a work-up; initial tests for elevated AST/ALT should include a hepatitis B and C panel (ALT levels will wax and wane in hepatitis C), iron and total iron-binding capacity, serum electrophoresis, and serum ceruplasmin.
Transferrin saturation can be calculated from the ratio of serum iron concentration to total iron-binding capacity (TIBC) expressed as a percentage [(serum iron/ TIBC) x 100] or, instead, using the sum of serum iron and unsaturated iron-binding capacity (UIBC): [TIBC.sub.calc] = serum iron + UIBC.
We reported recently that total iron-binding capacity (TIBC) values calculated from serum iron and unsaturated iron-binding capacity (UIBC) values were significantly lower than those obtained by a direct and fully automated TIBC assay (1, 2).
Adding measures of serum iron and total iron-binding capacity will help identify problems in women who are runners.

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