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Toluenesulfonyl radical, widely used to block amino groups in the course of organic syntheses of drugs and other biologically active compounds.
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References in periodicals archive ?
Awada and Daneault [62] prepared chemically modified PVA containing tosyl, azide, and amin functional groups that were attached to the carbon backbone.
In the second step the tosyl chloride was reacted with substituted benzimidazoles in basic conditions to afford the title N-tosyl benzimidazoles (4a-e).
HEPES, sodium chloride, ammonium formate, urea, tris base, iodoacetamide, and tosyl lysyl chloromethyl ketone were purchased from Sigma Aldrich.
Ryousuke Hayashi, "Solution copolycondensation of isophthalic acid, terephthalic acid, 4,4/dihydroxydiphenylsulfone, and bisphenols with a tosyl chloride/dimethylformamide/pyridine condensing agent," Journal of Applied Polymer Science, vol.
Pellacani, "Role of the tosyl group in the coordination ability of N-protected amino acids.
The viruses were cultured for 2 days in Madin-Darby Canine Kidney (MDCK) cells with tosyl sulfonyl phenylalanyl chloromethyl ketone(TPCK-) treated trypsin (2 [micro]g/ml) (Sigma, St.
N-a-Benzoyl-l-arginine ethyl ester (BAEE) and trypsin (TPCK (tosyl phenylalanyl chloromethyl ketone) treated trypsin) were purchased from Sigma-Aldrich Co., USA: chitosan (CTS), iron(II) sulfate heptahydrate (Fe[O.sub.4] x 7[H.sub.2]O), 25% ammonia solution (N[H.sub.3] x [H.sub.2]O), iron(III) chloride hexahydrate (Fe[Cl.sub.3] x 6[H.sub.2]O), ammonium bicarbonate (N[H.sub.4]HC[O.sub.3]), acetic acid, glutaraldehyde, liquid paraffin, Tween-80, magnesium stearate, ethyl ether, acetone, ethanol, bovine serum albumin (BSA), and pure water (with an electrical resistivity of 18.2 M[ohm] cm).
With this background, the substitution of the C3-OH of (2R,3S) 5,7,3',4'-tetramethoxyflavan-3-ol (catechin) 8 and (2R,3R) 5,7,3',4'-tetramethoxyflavan-3-ol (epicatechin) 9 with a good leaving group, such as a tosyl or mesyl group, has been hypothesized to synthesize a range of flavonoids and optically active substituted flav-3-enes.
Besides these functional groups, preactivated magnetic beads with different functional groups are available such as tosyl or epoxy groups [78, 83].
Free tosyl groups on the beads were blocked with Buffer C (500 [micro]L; 4 h, 37[degrees]C), followed by washing with Buffer B (500 [micro]L; 5 min, 4[degrees]C).
Thymine, adenine, citric acid, potassium hydroxide, dichloromethane, diethyl ether, triethylamine, [alpha]-cyclodextrin, dimethylformamide, tosyl chloride, and fluorescein were purchased from Merck (Germany).
To the suspension solution of 3 (0.3 g, 0.58 mmol) in DCM (15 mL) and [NEt.sub.3] (5mL), tosyl chloride (0.443 g, 2.32 mmol) was slowly added.