torsades de pointes


Also found in: Acronyms, Wikipedia.

torsades de pointes

 [tor-sahd´ duh pwahnt]
an atypical rapid ventricular tachycardia with periodic waxing and waning of amplitude of the QRS complexes on the electrocardiogram. It is usually drug related and may be either self-limiting or progressing to ventricular fibrillation.

torsades de pointes

[tôrsäd′ de pô·aNt′, tôr′sād də point′]
Etymology: Fr, torsader, to twist together, pointes, tips
a type of ventricular tachycardia with a spiral-like appearance ("twisting of the points") and complexes that at first look positive and then negative on an electrocardiogram. It is precipitated by a long Q-T interval, which often is induced by drugs (quinidine, procainamide, or disopyramide) but which may be the result of hypokalemia, hypomagnesemia, or profound bradycardia. The first line of treatment is IV magnesium sulfate, as well as defibrillation if the patient is unstable. See also long QT syndrome.
References in periodicals archive ?
Electrocardiographic and clinical predictors of torsades de pointes induced by almokalant infusion in patients with chronic atrial fibrillation or flutter: a prospective study.
A 2007 Mayo Clinic study reported no documented cases of torsades de pointes in the 16,791 patients exposed to droperidol over the 3-year period preceding the black box warning, and the authors concluded the FDA warning for low-dose droperidol was excessive and unnecessary (Anesthesiology 2007; 107:531-6).
Because of this difficulty and the rarity of serious AEs, drugs that cause torsades de pointes may not be identified during preclinical testing and clinical trials.
17, states that there have been at least 28 case reports of QT prolongation and torsades de pointes (TdP) in haloperidol-treated patients in the medical literature, including some with fatal outcomes, "especially when the drug is administered intravenously or in higher doses than recommended.
1,13) Torsades de pointes may self-terminate, and normal sinus rhythm may resume.
Monitoring for QT interval prolongation and torsades de pointes
Straker listed torsades de pointes, cardiac and cerebrovascular events, diabetic ketoacidosis, significant extrapyramidal effects or akathisia, dysphagia, and falls.
1-3) These agents may expose patients to rare but serious complications such as ventricular arrhythmias, including torsades de pointes (TdP).
Arizona CERT also maintains the International Registry of Drug-induced Arrhythmias, designed to investigate the pharmacogenetics of drug-induced long QT syndrome and torsades de pointes ventricular arrhythmias.
By using echocardiographic techniques, they have also identified fetal torsades de pointes, which were then treated in utero with lidocaine.