Electrocardiographic and clinical predictors of torsades de pointes
induced by almokalant infusion in patients with chronic atrial fibrillation or flutter: a prospective study.
A 2007 Mayo Clinic study reported no documented cases of torsades de pointes
in the 16,791 patients exposed to droperidol over the 3-year period preceding the black box warning, and the authors concluded the FDA warning for low-dose droperidol was excessive and unnecessary (Anesthesiology 2007; 107:531-6).
Because of this difficulty and the rarity of serious AEs, drugs that cause torsades de pointes
may not be identified during preclinical testing and clinical trials.
17, states that there have been at least 28 case reports of QT prolongation and torsades de pointes
(TdP) in haloperidol-treated patients in the medical literature, including some with fatal outcomes, "especially when the drug is administered intravenously or in higher doses than recommended.
Taking the "idio" out of "idiosyncratic": predicting torsades de pointes
1,13) Torsades de pointes
may self-terminate, and normal sinus rhythm may resume.
Conclusion: Torsades de Pointes
during CAVB was rare among our patient population.
Monitoring for QT interval prolongation and torsades de pointes
Straker listed torsades de pointes
, cardiac and cerebrovascular events, diabetic ketoacidosis, significant extrapyramidal effects or akathisia, dysphagia, and falls.
1-3) These agents may expose patients to rare but serious complications such as ventricular arrhythmias, including torsades de pointes
Arizona CERT also maintains the International Registry of Drug-induced Arrhythmias, designed to investigate the pharmacogenetics of drug-induced long QT syndrome and torsades de pointes
By using echocardiographic techniques, they have also identified fetal torsades de pointes
, which were then treated in utero with lidocaine.