Las interacciones farmacologicas de medicamentos con carga anticolinergica moderada y alta, inducen a un mayor riesgo de cardiotoxicidad, debido a la prolongacion del QTc (intervalo Qt corregido), lo que podria llevar a torsade
de pointes (TdP), especialmente por antidepresivos triciclicos y antipsicoticos atipicos en combinacion con otros medicamentos con carga anticolinergica, como los antiparkinsonianos (Amantadina), antibioticos y antihistaminicos (34, 35).
While sotalol administration increases iCEB and causes torsade
de Pointes (TdP), flecainide usage decreases iCEB and causes non-TdP ventricular tachycardia or ventricular fibrillation (10).
Viskin, "Long QT syndromes and torsade
de pointes," The Lancet, vol.
Several case reports showed that donepezil could lead rarely to serious bradycardia needing pacemaker implantation and fatal ventricular arrhythmia (torsade
de pointes (TdP)) [7,8].
Monomorphic VT occur in 83 (65.35%), polymorphic VT occurred in 19 (14.96%), torsade
depointes in 9 (7.08%) and ventricular fibrillation in 16 (12.6%) patients.
 Another effect of arsenic is that it can cause QT interval prolongation and can even result in life-threatening ventricular arrhythmia, torsades
de pointes, which is can even lead to cardiac death.
Anderson, "Antipsychotic-related QTc prolongation, torsade
de pointes and sudden death," Drugs, vol.
Murphy, "QT prolongation and torsades
de pointes after administration of FK506," Transplantation, vol.
Electrocardiography abnormalities such as atrial flutter, atrioventricular block, torsade
de pointes, sinus tachycardia, QT prolongation, ST elevation, and T wave inversion were detected in seven patients.
de pointes associated with fluoroquinolones.
These can include arrhythmias such as Torsades
de Pointes and Ventricular Fibrillation, which may ultimately lead to death.
Drug induced prolongation of QTc interval has become the first cause of withdrawal or restricted use of the drug in the past years because of potential risk of life threatening polymorphic ventricular tachycardia and torsades